吡啶盐光催化α-C(sp3) -H芳基化/杂芳基化的研究

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-03-06 DOI:10.1021/acs.joc.5c00090

Jiemin Ma, Yuhua Zhong, Hu Cai, Wentao Xu

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引用次数: 0

摘要

开发了一种光催化α-C(sp3) -H芳基化/杂芳基化的方法。在新设计的DPA-TPT存在下，该反应可以在温和的条件下进行，并以较高的收率生产多种叔苯胺。此外，丁卡因的后期芳基化证明了该方案的实际应用，突出了其在复杂分子功能化方面的通用性和效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Photocatalytic α-C(sp3)–H Arylation/Heteroarylation of Amines Enabled by Pyrylium Salt

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Photocatalytic α-C(sp3)–H Arylation/Heteroarylation of Amines Enabled by Pyrylium Salt

A general photocatalytic α-C(sp³)–H arylation/heteroarylation of amines has been developed. In the presence of the newly designed DPA-TPT, the reaction can operate under mild conditions and produce a diverse array of tertiary benzylic amines in good yields. Additionally, the late-stage arylation of tetracaine demonstrated the practical application of this protocol, highlighting its versatility and efficiency in functionalizing complex molecules.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.