蛋白质废物变成了抗生素，作为人类细胞的一种防御策略

IF 48.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Pub Date : 2025-03-05 DOI:10.1038/d41586-025-00514-4

Tim Clausen

引用次数: 0

摘要

在感染过程中，蛋白酶体的裂解发生变化以产生抗生素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Protein waste turned into antibiotics as a defence strategy of human cells

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Protein waste turned into antibiotics as a defence strategy of human cells

As well as degrading proteins, the proteosome surprisingly also functions in human defence against bacterial infection. By changing how proteins are cleaved, this system generates antibiotic peptides on demand. Proteasome cleavage changes during infection to generate antibiotics.

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来源期刊

Nature 综合性期刊-综合性期刊

CiteScore

90.00

自引率

1.20%

发文量

3652

审稿时长

3 months

期刊介绍： Nature is a prestigious international journal that publishes peer-reviewed research in various scientific and technological fields. The selection of articles is based on criteria such as originality, importance, interdisciplinary relevance, timeliness, accessibility, elegance, and surprising conclusions. In addition to showcasing significant scientific advances, Nature delivers rapid, authoritative, insightful news, and interpretation of current and upcoming trends impacting science, scientists, and the broader public. The journal serves a dual purpose: firstly, to promptly share noteworthy scientific advances and foster discussions among scientists, and secondly, to ensure the swift dissemination of scientific results globally, emphasizing their significance for knowledge, culture, and daily life.