Xuemei Wang, Huimin Chen, Xinxin Ma, Huijing Liu, Dongdong Wu, Wei Du, Jing He, Shuhua Li, Haibo Chen, Tao Wu, Tao Feng, Wen Su
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引用次数: 0
摘要
有关帕金森病（PD）中与步态冻结（FOG）相关的脑结构萎缩的证据并不一致。我们在两个大型帕金森病队列中使用 FreeSurfer 分析了皮层厚度和皮层下核体积。在队列 1（N = 316）中，多变量分析发现苍白球和腹侧间脑（VDC）体积的减少与 FOG 的存在显著相关。帕金森病进展标志物倡议（PPMI）队列（队列 2，N = 94）的验证结果表明，随访四年时 VDC 体积的减少可独立预测较高的 FOG 风险，与 PIGD 评分、CSF Aβ42 和尾状体 DAT 摄取相结合可提高预测模型的准确性（AUC 0.760；Δχ2 = 5.449，P = 0.020；Z = 2.211，P = 0.027）。VDC 的体积也与 FOG 的严重程度相关。这些发现表明，VDC萎缩可能是FOG机制的基础，并可作为PD患者FOG进展的生物标志物。
Atrophy of ventral diencephalon is associated with freezing of gait in Parkinson’s disease: analysis of two cohorts
Evidence regarding brain structural atrophy associated with Freezing of Gait (FOG) in Parkinson’s disease (PD) is inconsistent. We analyzed cortical thickness and subcortical nuclei volumes using FreeSurfer in two large PD cohorts. In cohort 1 (N = 316), multivariate analyses identified reduced pallidum and ventral diencephalon (VDC) volumes as significantly associated with FOG presence. Validation in the Parkinson’s Progression Markers Initiative (PPMI) cohort (cohort 2, N = 94) demonstrated that decreased VDC volume at four-year follow-up independently predicted higher FOG risk, improving the predictive model’s accuracy when combined with PIGD score, CSF Aβ42, and caudate DAT uptake (AUC 0.760; Δχ2 = 5.449, P = 0.020; Z = 2.211, P = 0.027). VDC volume is also correlated with FOG severity. These findings suggest that VDC atrophy may underlie FOG mechanisms and serve as a biomarker for its progression in PD patients.
期刊介绍：
npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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