冷浸衍生橄榄链霉菌HDN22-001的硫代二酮哌嗪衍生物雪霉素A-B和安霉素衍生物散维内酯X。

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Antibiotics Pub Date : 2025-03-04 DOI:10.1038/s41429-025-00812-z

Chen Li, Jiangli Cheng, Ruojin Liu, Xiaofei Huang, Luning Zhou, Guojian Zhang, Tianjiao Zhu, Dehai Li, Qian Che

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引用次数: 0

摘要

从南海深海冷渗漏沉积物中提取的海洋放线菌链霉菌（Streptomyces olivaceus HDN22-001）的培养物中分离鉴定出3个新化合物，包括2个硫代二酮哌嗪衍生物shovelmycins a - b（1-2）和1个安霉素衍生物divergolide X(3)。通过光谱分析和ECD计算确定了它们的结构和绝对构型。化合物1对DPPH自由基的清除能力最强，IC50值为10.83 μM，优于阳性对照维生素c；化合物2对NCl-H446细胞具有中等细胞毒性，IC50值为26.6 μM。

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The thiodiketopiperazine derivatives shovelmycin A-B and ansamycin derivative divergolide X from the cold-seep-derived Streptomyces olivaceus HDN22-001.

Three new compounds including two thiodiketopiperazine derivatives shovelmycins A-B (1-2), and one ansamycin derivative divergolide X (3) were isolated and identified from the culture extract of Streptomyces olivaceus HDN22-001, a marine actinomycete obtained from the deep-sea cold seep sediment sample collected from the South China Sea. Their structures and absolute configurations were determined by spectroscopic analyses and ECD calculations. Compound 1 exhibited the strongest DPPH radical scavenging activity with an IC₅₀ value of 10.83 μM, which was better than that of the positive control vitamin C. And compound 2 was modestly cytotoxic against NCl-H446 cell with the IC₅₀ value of 26.6 μM.

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来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.