Xinyi Shao, Yi Ou, Tingqiao Chen, Binbin Deng, Jingbo Zhang, Jin Chen
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引用次数: 0
摘要
背景：关于血清微量元素水平与免疫介导的炎症性皮肤病（IMSDs）之间关系的证据不一致。目的：在这项系统回顾和荟萃分析中，我们旨在评估选定的血清微量元素水平（锌[Zn]、铜[Cu]、铁[Fe]、硒[Se]和钙[Ca]）与IMSDs（牛皮癣、白癜风、特应性皮炎[AD]、斑秃[AA]、化脓性汗腺炎和大疱性疾病）之间的关系。数据来源：我们对PubMed、EMBASE、Scopus、中国知识基础设施和Web of Science数据库从建库日期到2024年5月2日进行了全面检索。研究测量了IMSD患者与健康对照组相比的血清、血浆或全血Zn、Cu、Fe、Se或Ca水平。资料提取：本研究遵循流行病学观察性研究荟萃分析指南以及系统评价和荟萃分析指南的首选报告项目。两位作者（X.Y.S.和Y.O.）使用标准化的收集表格独立审查了已确定的研究的标题和摘要。数据分析：主要结局是imsd患者与健康对照者血清微量元素水平（Zn、Cu、Fe、Se和Ca）的标准化平均差异，95% CI。meta分析共纳入113项研究，涉及7014例IMSD患者。与健康对照组相比，白癜风、银屑病和AA患者血清锌水平降低；银屑病、AD和AA患者血清铜水平升高；银屑病和AD患者血清硒和铁水平下降。结论：IMSDs患者血清微量元素水平变化明显高于健康对照组。这些发现提示微量元素水平的改变可能与imsd的发生、发展和预后有关。
Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.
Context: Evidence regarding the relationship between serum trace element levels and immune-mediated inflammatory skin diseases (IMSDs) is inconsistent.
Objective: In this systematic review and meta-analysis we aimed to evaluate the association between selected serum trace element levels (zinc [Zn], copper [Cu], iron [Fe], selenium [Se], and calcium [Ca]) and IMSDs (psoriasis, vitiligo, atopic dermatitis [AD], alopecia areata [AA], hidradenitis suppurativa, and bullous diseases).
Data sources: We conducted a comprehensive search on the PubMed, EMBASE, Scopus, China National Knowledge Infrastructure, and Web of Science databases from the database inception date to May 2, 2024. Studies measuring serum, plasma, or whole-blood levels of Zn, Cu, Fe, Se, or Ca in patients with IMSD compared to those in healthy controls were included.
Data extraction: This study followed the guidelines of the Meta-analysis of Observational Studies in Epidemiology and the Preferred Reporting Items for Systematic Review and Meta-analyses guidelines. Two authors (X.Y.S. and Y.O.) independently reviewed the titles and abstracts of the identified studies using a standardized collection form.
Data analysis: The primary outcome was the standardized mean difference with a 95% CI in serum trace element levels (Zn, Cu, Fe, Se, and Ca) between patients with IMSDs and healthy controls. Overall, 113 studies involving 7014 patients with IMSD were included in the meta-analysis. Compared with those in the healthy control group, serum Zn levels decreased in patients with vitiligo, psoriasis, and AA; serum Cu levels increased in patients with psoriasis, AD, and AA; serum Se and Fe levels decreased in patients with psoriasis and AD.
Conclusion: Serum trace element levels showed more significant changes in patients with IMSDs than in healthy controls. These findings suggest that alterations in trace element levels may be associated with the occurrence, development, and prognosis of IMSDs.
期刊介绍：
Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.
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