Furong Yang, Ming Zhang, Xiangdong Pu, Chuanpu Shen
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引用次数: 0
摘要
苦味受体属于 G 蛋白偶联受体 GPCR 超家族的 A 类。苦味受体在不同物种中有不同的数量和结构，对它们的结构进行分析有助于发现和开发它们的激动剂和抑制剂。此外，苦味受体在不同物种和组织中的表达也不同，这与其作用机制的多样性和特异性相对应。目前，苦味受体对胃肠道、气道、心脏、骨科、泌尿系统疾病和癌症等疾病的治疗也具有广泛的作用。因此，本文综述了苦味受体的结构、表达、功能和作用机制，以期开发出更多用于治疗的苦味受体和苦味配体，为苦味药物的临床应用提供一些新的思路和目标。
The appearance of bitter taste receptors - inspiration from structure, expression, function, and mechanism.
Bitter taste receptors belong to the class A of the GPCR superfamily of G protein-coupled receptors. Bitter taste receptors have different numbers and structures in different species, and an analysis of their structures facilitates the discovery and development of their agonists and inhibitors. In addition, bitter taste receptors differ in expression between species and tissues, which corresponds to the diversity and specificity of their mechanisms of action. At present, bitter taste receptors also have a wide range of effects on the treatment of diseases, including gastrointestinal, airway, heart, orthopedic, urinary disease, and cancer. Therefore, this article reviewed the structure, expression, function, and mechanism of bitter taste receptors, in order to develop more bitter taste receptors and bitter ligands for treatment, and provide some new ideas and goals for the clinical use of bitter drugs.
期刊介绍：
Naunyn-Schmiedeberg''s Archives of Pharmacology was founded in 1873 by B. Naunyn, O. Schmiedeberg and E. Klebs as Archiv für experimentelle Pathologie und Pharmakologie, is the offical journal of the German Society of Experimental and Clinical Pharmacology and Toxicology (Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, DGPT) and the Sphingolipid Club. The journal publishes invited reviews, original articles, short communications and meeting reports and appears monthly. Naunyn-Schmiedeberg''s Archives of Pharmacology welcomes manuscripts for consideration of publication that report new and significant information on drug action and toxicity of chemical compounds. Thus, its scope covers all fields of experimental and clinical pharmacology as well as toxicology and includes studies in the fields of neuropharmacology and cardiovascular pharmacology as well as those describing drug actions at the cellular, biochemical and molecular levels. Moreover, submission of clinical trials with healthy volunteers or patients is encouraged. Short communications provide a means for rapid publication of significant findings of current interest that represent a conceptual advance in the field.
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