{"title":"镁合金固定螺钉在山羊股骨髁骨折模型中的疗效评价。","authors":"Bin Li, Yong Yang, Liying Sun, Feng Li, Yu Zhang, Wen Tian","doi":"10.1177/08853282251324799","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigated the efficacy and safety of magnesium alloy screws in repairing small bone fractures using goat lateral femoral condyle fracture models. The animals were randomized into an experimental group receiving magnesium alloy screws (CS/Ф 3.2 × 28 mm, Suzhou Zhuoqia Medical Technology) and a control group receiving titanium alloy screws (CS/Ф 3.2 × 28 mm, Samo Medical Technology Co., Ltd). Postoperative evaluations at 3- and 6-month intervals included assessments of fracture repair, animal health, hematological parameters, histology, and screw degradation. Hematological tests revealed no significant intergroup variations. While gas accumulation near the magnesium screws was noted, the fracture healing outcomes were similar between the magnesium and titanium screw groups, with no deleterious health effects attributed to magnesium screw degradation. Gas liberation during magnesium degradation had no detrimental effect on small fracture recovery. Magnesium screw implementation appears to present no general health risks. Consequently, magnesium alloy could be a promising biomaterial for future fixation screw applications in orthopedics.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"92-104"},"PeriodicalIF":2.5000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of the efficacy of magnesium alloy fixation screws in a goat femoral condylar fracture model.\",\"authors\":\"Bin Li, Yong Yang, Liying Sun, Feng Li, Yu Zhang, Wen Tian\",\"doi\":\"10.1177/08853282251324799\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study investigated the efficacy and safety of magnesium alloy screws in repairing small bone fractures using goat lateral femoral condyle fracture models. The animals were randomized into an experimental group receiving magnesium alloy screws (CS/Ф 3.2 × 28 mm, Suzhou Zhuoqia Medical Technology) and a control group receiving titanium alloy screws (CS/Ф 3.2 × 28 mm, Samo Medical Technology Co., Ltd). Postoperative evaluations at 3- and 6-month intervals included assessments of fracture repair, animal health, hematological parameters, histology, and screw degradation. Hematological tests revealed no significant intergroup variations. While gas accumulation near the magnesium screws was noted, the fracture healing outcomes were similar between the magnesium and titanium screw groups, with no deleterious health effects attributed to magnesium screw degradation. Gas liberation during magnesium degradation had no detrimental effect on small fracture recovery. Magnesium screw implementation appears to present no general health risks. Consequently, magnesium alloy could be a promising biomaterial for future fixation screw applications in orthopedics.</p>\",\"PeriodicalId\":15138,\"journal\":{\"name\":\"Journal of Biomaterials Applications\",\"volume\":\" \",\"pages\":\"92-104\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biomaterials Applications\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1177/08853282251324799\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomaterials Applications","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/08853282251324799","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/4 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Evaluation of the efficacy of magnesium alloy fixation screws in a goat femoral condylar fracture model.
This study investigated the efficacy and safety of magnesium alloy screws in repairing small bone fractures using goat lateral femoral condyle fracture models. The animals were randomized into an experimental group receiving magnesium alloy screws (CS/Ф 3.2 × 28 mm, Suzhou Zhuoqia Medical Technology) and a control group receiving titanium alloy screws (CS/Ф 3.2 × 28 mm, Samo Medical Technology Co., Ltd). Postoperative evaluations at 3- and 6-month intervals included assessments of fracture repair, animal health, hematological parameters, histology, and screw degradation. Hematological tests revealed no significant intergroup variations. While gas accumulation near the magnesium screws was noted, the fracture healing outcomes were similar between the magnesium and titanium screw groups, with no deleterious health effects attributed to magnesium screw degradation. Gas liberation during magnesium degradation had no detrimental effect on small fracture recovery. Magnesium screw implementation appears to present no general health risks. Consequently, magnesium alloy could be a promising biomaterial for future fixation screw applications in orthopedics.
期刊介绍:
The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials.
Peer-reviewed articles by biomedical specialists from around the world cover:
New developments in biomaterials, R&D, properties and performance, evaluation and applications
Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices
Current findings in biological compatibility/incompatibility of biomaterials
The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use.
The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.