Adam Finn, Nicole Guiso, Carl Heinz Wirsing von König, Federico Martinón-Torres, Arto A Palmu, Paolo Bonanni, Pierre Bakhache, Helena C Maltezou, Pierre Van Damme
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How to improve pertussis vaccination in pregnancy: a European expert review.
Introduction: Pertussis vaccination in pregnancy is a safe and highly effective strategy to protect young infants against severe pertussis, but cases continue to occur. In November 2023, the authors of this paper met to discuss difficulties faced by pertussis vaccination programs in pregnant women in Europe, and the need and potential for new vaccines.
Areas covered: We summarize current pertussis epidemiology, the status of pertussis vaccination in pregnancy in Europe, followed by a summary of the meeting on benefits of pertussis-only vaccines and pertussis vaccines with improved immunogenicity, including a review of available vaccines.
Expert opinion: Ongoing surveillance and registers documenting vaccine uptake in pregnant women are important to monitor changes in pertussis epidemiology and estimated effectiveness of maternal pertussis vaccination programs in individual countries. While current programs have been effective, Tdap or Tdap-IPV combined vaccines are not the ideal choice but are the only vaccines available for pertussis immunization in pregnancy in Europe. Pertussis-only vaccine would avoid exposing women to unnecessary tetanus and diphtheria boosters in every pregnancy. Recombinant pertussis vaccines with higher immunogenicity could prolong passive immune protection against pertussis in young infants.
期刊介绍：
Expert Review of Vaccines (ISSN 1476-0584) provides expert commentary on the development, application, and clinical effectiveness of new vaccines. Coverage includes vaccine technology, vaccine adjuvants, prophylactic vaccines, therapeutic vaccines, AIDS vaccines and vaccines for defence against bioterrorism. All articles are subject to rigorous peer-review.
The vaccine field has been transformed by recent technological advances, but there remain many challenges in the delivery of cost-effective, safe vaccines. Expert Review of Vaccines facilitates decision making to drive forward this exciting field.
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