99mTc-FAPI-46在良性甲状腺结节和混合性浸润性导管性乳腺癌同时发生中的摄取。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-05-01 Epub Date: 2025-03-05 DOI:10.1097/RLU.0000000000005729

Nasrin Raeisi, Amin Saber Tanha, Kamran Aryana, Mahsa Akbari Oryani, Somaye Barashki

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引用次数: 0

摘要

我们报告一例65岁的女性诊断为混合性粘液浸润性导管癌，一种罕见的乳腺癌亚型。利用99mTc-FAPI-46闪烁成像，我们观察到乳腺肿块和转移性腋窝淋巴结的高靶本底比。值得注意的是，在甲状腺中也检测到良性滤泡结节，没有99mTc-FAPI摄取。我们的研究结果表明99mTc-FAPI-46与68Ga-FAPI具有相似的特征，并且可能优于18F-FDG PET/CT在粘液性乳腺癌中的表现。本病例强调了FAPI作为恶性肿瘤预测生物标志物的潜力及其在良性肿瘤中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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99m Tc-FAPI-46 Uptake in Simultaneous Occurrence of Benign Thyroid Nodule and Mixed-Mucinous-Invasive Ductal Breast Carcinoma.

We present a case of a 65-year-old woman diagnosed with mixed mucinous-invasive ductal carcinoma, a rare subtype of breast cancer. Utilizing 99m Tc-FAPI-46 scintigraphy, we observed a high target-to-background ratio in the breast mass and metastatic axillary lymph nodes. Notably, a benign follicular nodule was also detected in the thyroid which showed absent 99m Tc-FAPI uptake. Our findings suggest that 99m Tc-FAPI-46 shares similar characteristics with 68 Ga-FAPI and may outperform 18 F-FDG PET/CT in mucinous breast cancer. This case highlights the potential of FAPI as a predictive biomarker for malignancy and its role in benign findings.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.