保留左心室射血分数的类风湿关节炎患者心肌功与疾病活动度的相关性：基于无创压力-应变环的回顾性研究。

IF 2.9 3区医学 Q2 RHEUMATOLOGY

Clinical Rheumatology Pub Date : 2025-03-05 DOI:10.1007/s10067-025-07380-5

Xiaolong Yu, Jing Xi, Jiabiao Wu, Ruixiao Song

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Patients were categorized into low (25), medium (18), and high (19) disease activity groups based on the 28 joint disease activity score (DAS28). A control group of 29 healthy individuals was also established. LV-PSL technology assessed left ventricular global longitudinal strain (GLS) and MW parameters: global constructive work (GCW), global wasted work (GWW), global work index (GWI), and global work efficiency (GWE). Correlations between MW parameters, GLS, LVEF, and DAS28 scores were analyzed. 2021 1 20239 62 LVEF RA 。 28 （DAS28）（25）、（18）（19）。 29 。LV-PSL （GLS） MW ：（GCW）、（GWW）、（GWI）（GWE）。 MW 、 GLS 、 LVEF DAS28 。 RESULTS: There were no significant differences in general data between study and control groups (p > 0.05). However, laboratory indicators (RF, CRP, ESR) showed significant differences (p < 0.05). GWI, GCW, GWE, and GLS were significantly lower in the high disease activity group compared to controls (p < 0.05). 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引用次数: 0

摘要

背景：早期心脏损伤在RA患者中很常见，但通常是亚临床的。因此，寻找一种无创的方法来早期发现和治疗自身免疫性疾病的心脏损伤就显得尤为重要。diac dam RA，。，。目的：应用左心室压力-应变环（LV-PSL）技术评价保留左心室射血分数（LVEF）的类风湿关节炎（RA）患者左心室功能的变化，探讨心肌功（MW）与疾病活动度的相关性。- (lv-psl) (lvef) (ra), （mw）。方法：共纳入2021年1月至2023年9月在江苏大学附属武进医院治疗的62例保留LVEF的RA患者。根据28关节疾病活动度评分（DAS28）将患者分为低（25）、中（18）和高（19）疾病活动度组。另设对照组29人。LV-PSL技术评估左心室整体纵向应变（GLS）和MW参数：整体构建功（GCW）、整体浪费功（GWW）、整体工作指数（GWI）和整体工作效率（GWE）。分析MW参数、GLS、LVEF和DAS28评分之间的相关性。2021 1 20239 62 lvef ra。28 (das28)(25),(18)（19）。29 。Lv-psl (gls) mw: (gcw), (gww), (gwi) （gwe）。Mw， GLS, lvef = 28。结果：研究组与对照组一般资料差异无统计学意义（p < 0.05）。实验室指标（RF、CRP、ESR）差异有统计学意义（p < 0.05）。，（RF， CRP， ESR）（p < 0.05）。GWI、GCW、GWE GLS （p < 0.05）。GWI， GCW, GWE LVEF， GLS, GWW LVEF （p < 0.05）。（p < 0.05）。，（RF， CRP， ESR）（p < 0.05）。GWI、GCW、GWE GLS （p < 0.05）。GWI， GCW, GWE LVEF， GLS, GWW LVEF （p < 0.05）。结论：RA疾病活动性与心肌功能受损密切相关。LV-PSL技术可有效监测RA患者心肌功能异常，为临床管理提供有价值的见解。•疾病活动度高的RA患者心肌功能明显受损。•左心室压力-应变环（LV-PSL）技术可有效评估该患者群体的心功能。•疾病活动度增加与心肌工作参数降低相关。

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Correlation between myocardial work and disease activity in rheumatoid arthritis patients with preserved left ventricular ejection fraction: a retrospective study based on non-invasive pressure-strain loop：.

Background: Early cardiac damage is very common in RA patients, but it is usually subclinical. Therefore, finding a non-invasive method for the early detection and treatment of cardiac damage in autoimmune diseases is particularly important.diac dam RA ，。，。 OBJECTIVE: To evaluate left ventricular function changes in rheumatoid arthritis (RA) patients with preserved left ventricular ejection fraction (LVEF) using left ventricular pressure-strain loop (LV-PSL) technology and to explore the correlation between myocardial work (MW) and disease activity.- （LV-PSL）（LVEF）（RA），（MW）。 METHODS: A total of 62 RA patients with preserved LVEF, treated at Wujin Hospital Affiliated with Jiangsu University from January 2021 to September 2023, were included. Patients were categorized into low (25), medium (18), and high (19) disease activity groups based on the 28 joint disease activity score (DAS28). A control group of 29 healthy individuals was also established. LV-PSL technology assessed left ventricular global longitudinal strain (GLS) and MW parameters: global constructive work (GCW), global wasted work (GWW), global work index (GWI), and global work efficiency (GWE). Correlations between MW parameters, GLS, LVEF, and DAS28 scores were analyzed. 2021 1 20239 62 LVEF RA 。 28 （DAS28）（25）、（18）（19）。 29 。LV-PSL （GLS） MW ：（GCW）、（GWW）、（GWI）（GWE）。 MW 、 GLS 、 LVEF DAS28 。 RESULTS: There were no significant differences in general data between study and control groups (p > 0.05). However, laboratory indicators (RF, CRP, ESR) showed significant differences (p < 0.05). GWI, GCW, GWE, and GLS were significantly lower in the high disease activity group compared to controls (p < 0.05). GWI, GCW, and GWE were positively correlated with LVEF and absolute GLS, while GWW correlated negatively with LVEF (p < 0.05). （p > 0.05）。，（RF、CRP、ESR）（p < 0.05）。， GWI、GCW、GWE GLS （p < 0.05）。GWI、GCW GWE LVEF GLS ， GWW LVEF （p < 0.05）。（p > 0.05）。，（RF、CRP、ESR）（p < 0.05）。， GWI、GCW、GWE GLS （p < 0.05）。GWI、GCW GWE LVEF GLS ， GWW LVEF （p < 0.05）。 CONCLUSION: RA disease activity is closely associated with impaired myocardial work. LV-PSL technology effectively monitors myocardial function abnormalities in RA patients, providing valuable insights for clinical management. Key Points • Myocardial work is significantly impaired in RA patients with high disease activity. • Left ventricular pressure-strain loop (LV-PSL) technology effectively assesses cardiac function in this patient population. • Increased disease activity correlates with reduced myocardial work parameters.

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来源期刊

Clinical Rheumatology 医学-风湿病学

CiteScore

6.90

自引率

2.90%

发文量

441

审稿时长

3 months

期刊介绍： Clinical Rheumatology is an international English-language journal devoted to publishing original clinical investigation and research in the general field of rheumatology with accent on clinical aspects at postgraduate level. The journal succeeds Acta Rheumatologica Belgica, originally founded in 1945 as the official journal of the Belgian Rheumatology Society. Clinical Rheumatology aims to cover all modern trends in clinical and experimental research as well as the management and evaluation of diagnostic and treatment procedures connected with the inflammatory, immunologic, metabolic, genetic and degenerative soft and hard connective tissue diseases.