Hinke van der Hoek MSc, Shosha H. M. Peersmann MSc, Heleen Maurice-Stam PhD, Gertjan J. L. Kaspers MD, PhD, Esther M. M. van den Bergh MSc, Wim J. E. Tissing MD, PhD, Leontien C. M. Kremer MD, PhD, Floor Abbink MD, MSc, Andrica C. H. de Vries MD, PhD, Jacqueline Loonen MD, PhD, Annemieke van Straten PhD, Martha A. Grootenhuis PhD, Raphaële R. L. van Litsenburg MD, PhD
{"title":"在线认知行为疗法对儿童癌症后青少年和年轻人失眠的影响：一项随机对照试验的结果","authors":"Hinke van der Hoek MSc, Shosha H. M. Peersmann MSc, Heleen Maurice-Stam PhD, Gertjan J. L. Kaspers MD, PhD, Esther M. M. van den Bergh MSc, Wim J. E. Tissing MD, PhD, Leontien C. M. Kremer MD, PhD, Floor Abbink MD, MSc, Andrica C. H. de Vries MD, PhD, Jacqueline Loonen MD, PhD, Annemieke van Straten PhD, Martha A. Grootenhuis PhD, Raphaële R. L. van Litsenburg MD, PhD","doi":"10.1002/cncr.35796","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Insomnia is common during and after childhood cancer and associated with negative health outcomes and impaired quality of life. Many adolescents and young adults do not receive treatment. Internet-delivered cognitive behavioral therapy for insomnia (iCBT-i) can fill this gap. This study assesses the effectiveness of the iCBT-i intervention “iSleep youth”.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Patients (12–30 years old) with an Insomnia Severity Index ≥8, ≥6 months after treatment, and <10 years after diagnosis were 1:1 randomized to iSleep youth or the wait list-control group. iSleep youth consists of five online sessions with a coach. Outcomes were sleep efficiency (actigraph-based), insomnia, fatigue, and health-related quality of life (HRQOL). Differences over time between iSleep youth and controls, 3 months (T3) and 6 months (T6) from baseline, were assessed with linear mixed models, controlling for age, sex, and time since end of treatment. iSleep youth also had a follow-up measurement after 12 months (T12).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Fifty-four (response rate, 49%) patients participated: 68.9% females, mean age, 18.5 years (SD = 3.5), and mean time since end of treatment 3.8 years (SD = 2.3). No significant effects between the two groups were found for sleep efficiency. However, iSleep youth had a beneficial effect on insomnia severity at T3 (β = –0.79) and T6 (β = –0.55), on fatigue at T3 (β = –1.08) and T6 (β = –0.52) and on HRQOL at T3 (β = 0.46) and T6 (β = 0.62). The scores did not change from T6 to T12 in iSleep youth.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>iSleep youth is effective in treating insomnia and concurrent fatigue in adolescents and young adults after childhood cancer and should be implemented.</p>\n </section>\n </div>","PeriodicalId":138,"journal":{"name":"Cancer","volume":"131 6","pages":""},"PeriodicalIF":5.1000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cncr.35796","citationCount":"0","resultStr":"{\"title\":\"The effect of online cognitive behavioral therapy for insomnia in adolescents and young adults after childhood cancer: Results from a randomized controlled trial\",\"authors\":\"Hinke van der Hoek MSc, Shosha H. M. Peersmann MSc, Heleen Maurice-Stam PhD, Gertjan J. L. Kaspers MD, PhD, Esther M. M. van den Bergh MSc, Wim J. E. Tissing MD, PhD, Leontien C. M. Kremer MD, PhD, Floor Abbink MD, MSc, Andrica C. H. de Vries MD, PhD, Jacqueline Loonen MD, PhD, Annemieke van Straten PhD, Martha A. Grootenhuis PhD, Raphaële R. L. van Litsenburg MD, PhD\",\"doi\":\"10.1002/cncr.35796\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Insomnia is common during and after childhood cancer and associated with negative health outcomes and impaired quality of life. Many adolescents and young adults do not receive treatment. Internet-delivered cognitive behavioral therapy for insomnia (iCBT-i) can fill this gap. This study assesses the effectiveness of the iCBT-i intervention “iSleep youth”.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Patients (12–30 years old) with an Insomnia Severity Index ≥8, ≥6 months after treatment, and <10 years after diagnosis were 1:1 randomized to iSleep youth or the wait list-control group. iSleep youth consists of five online sessions with a coach. Outcomes were sleep efficiency (actigraph-based), insomnia, fatigue, and health-related quality of life (HRQOL). Differences over time between iSleep youth and controls, 3 months (T3) and 6 months (T6) from baseline, were assessed with linear mixed models, controlling for age, sex, and time since end of treatment. iSleep youth also had a follow-up measurement after 12 months (T12).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Fifty-four (response rate, 49%) patients participated: 68.9% females, mean age, 18.5 years (SD = 3.5), and mean time since end of treatment 3.8 years (SD = 2.3). No significant effects between the two groups were found for sleep efficiency. However, iSleep youth had a beneficial effect on insomnia severity at T3 (β = –0.79) and T6 (β = –0.55), on fatigue at T3 (β = –1.08) and T6 (β = –0.52) and on HRQOL at T3 (β = 0.46) and T6 (β = 0.62). 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The effect of online cognitive behavioral therapy for insomnia in adolescents and young adults after childhood cancer: Results from a randomized controlled trial
Background
Insomnia is common during and after childhood cancer and associated with negative health outcomes and impaired quality of life. Many adolescents and young adults do not receive treatment. Internet-delivered cognitive behavioral therapy for insomnia (iCBT-i) can fill this gap. This study assesses the effectiveness of the iCBT-i intervention “iSleep youth”.
Methods
Patients (12–30 years old) with an Insomnia Severity Index ≥8, ≥6 months after treatment, and <10 years after diagnosis were 1:1 randomized to iSleep youth or the wait list-control group. iSleep youth consists of five online sessions with a coach. Outcomes were sleep efficiency (actigraph-based), insomnia, fatigue, and health-related quality of life (HRQOL). Differences over time between iSleep youth and controls, 3 months (T3) and 6 months (T6) from baseline, were assessed with linear mixed models, controlling for age, sex, and time since end of treatment. iSleep youth also had a follow-up measurement after 12 months (T12).
Results
Fifty-four (response rate, 49%) patients participated: 68.9% females, mean age, 18.5 years (SD = 3.5), and mean time since end of treatment 3.8 years (SD = 2.3). No significant effects between the two groups were found for sleep efficiency. However, iSleep youth had a beneficial effect on insomnia severity at T3 (β = –0.79) and T6 (β = –0.55), on fatigue at T3 (β = –1.08) and T6 (β = –0.52) and on HRQOL at T3 (β = 0.46) and T6 (β = 0.62). The scores did not change from T6 to T12 in iSleep youth.
Conclusions
iSleep youth is effective in treating insomnia and concurrent fatigue in adolescents and young adults after childhood cancer and should be implemented.
期刊介绍：
The CANCER site is a full-text, electronic implementation of CANCER, an Interdisciplinary International Journal of the American Cancer Society, and CANCER CYTOPATHOLOGY, a Journal of the American Cancer Society.
CANCER publishes interdisciplinary oncologic information according to, but not limited to, the following disease sites and disciplines: blood/bone marrow; breast disease; endocrine disorders; epidemiology; gastrointestinal tract; genitourinary disease; gynecologic oncology; head and neck disease; hepatobiliary tract; integrated medicine; lung disease; medical oncology; neuro-oncology; pathology radiation oncology; translational research
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