基于近十二硼酸阴离子和含硫氨基酸的硼化氨基化合物的合成

IF 1.8 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Russian Journal of Inorganic Chemistry Pub Date : 2025-01-20 DOI:10.1134/S0036023624603556

M. N. Ryabchikova, N. K. Neumolotov, A. V. Nelyubin, N. A. Selivanov, A. Yu. Bykov, A. P. Zhdanov, K. Yu. Zhizhin, N. T. Kuznetsov

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引用次数: 0

摘要

建立了以[B12H11NHC(NHCHR’cooh)R] -型氨基酸为基础合成硼化脒的新方法，可显著提高目标化合物的收率。研究了近十二硼酸阴离子与含硫氨基酸共轭物的合成过程。这些衍生物显示出开发硼中子捕获治疗（BNCT）新药物的巨大潜力，这些药物是基于通过多肽合成方法共轭的含载体基团的硼包覆金纳米颗粒。

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Synthesis of Borylated Amidines Based on Closo-Dodecaborate Anion and Sulfur-Containing Amino Acids

IA new method for synthesizing boronated amidines based on amino acids of the type [B₁₂H₁₁NHC(NHCHR'COOH)R]^– has been developed, which significantly increases the yield of target compounds. The process of obtaining conjugates of the closo-dodecaborate anion and sulfur-containing amino acids was studied. These derivatives show high potential for the development of new agents for BNCT (boron neutron capture therapy) based on boron-coated gold nanoparticles containing vector groups conjugated through peptide synthesis methods.

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来源期刊

Russian Journal of Inorganic Chemistry 化学-无机化学与核化学

CiteScore

3.10

自引率

38.10%

发文量

237

审稿时长

3 months

期刊介绍： Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.