Wei Wu, En Han, Lixin Ma, Ruiyun Zhou, Chen Wang, Junwen Bai, Jianrong Cai
{"title":"基于双金属 Au@Ag 纳米立方体的最佳 SERS 传感器，用于无标记超灵敏检测鸡蛋中的氟苯尼考残留量","authors":"Wei Wu, En Han, Lixin Ma, Ruiyun Zhou, Chen Wang, Junwen Bai, Jianrong Cai","doi":"10.1007/s00604-025-07076-2","DOIUrl":null,"url":null,"abstract":"<div><p>A label-free surface-enhanced Raman scattering (SERS) sensor using optimal bimetallic Au@Ag nanocuboids (Au@Ag NCs) was developed for ultrasensitive detection of florfenicol residue in eggs. The Raman characteristic peaks of florfenicol detection were identified at 1145 cm<sup>−1</sup> and 1595 cm<sup>−1</sup> which were consistent with the theoretical Raman spectrum of florfenicol calculated by density functional theory. The Au@Ag NCs were optimized by changing the aspect ratio of Au nanorods and the thickness of Ag nanocuboids, achieving an enhancement factor of 1.69 × 10<sup>6</sup> for SERS signals. Under optimal conditions, the label-free SERS sensor demonstrated a broad linear range of 0.01 mg/kg to 100 mg/kg for florfenicol in real sample. The limit of detection of florfenicol in eggs was as low as 0.0410 μg/kg, and the recovery was 94.83% ~ 108.24%. Therefore, this label-free SERS sensor offers a rapid and sensitive approach for the trace detection of florfenicol residues in food safety monitoring.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 4","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00604-025-07076-2.pdf","citationCount":"0","resultStr":"{\"title\":\"Optimal bimetallic Au@Ag nanocuboids-based SERS sensor for label-free ultrasensitive detection of florfenicol residue in eggs\",\"authors\":\"Wei Wu, En Han, Lixin Ma, Ruiyun Zhou, Chen Wang, Junwen Bai, Jianrong Cai\",\"doi\":\"10.1007/s00604-025-07076-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A label-free surface-enhanced Raman scattering (SERS) sensor using optimal bimetallic Au@Ag nanocuboids (Au@Ag NCs) was developed for ultrasensitive detection of florfenicol residue in eggs. The Raman characteristic peaks of florfenicol detection were identified at 1145 cm<sup>−1</sup> and 1595 cm<sup>−1</sup> which were consistent with the theoretical Raman spectrum of florfenicol calculated by density functional theory. The Au@Ag NCs were optimized by changing the aspect ratio of Au nanorods and the thickness of Ag nanocuboids, achieving an enhancement factor of 1.69 × 10<sup>6</sup> for SERS signals. Under optimal conditions, the label-free SERS sensor demonstrated a broad linear range of 0.01 mg/kg to 100 mg/kg for florfenicol in real sample. The limit of detection of florfenicol in eggs was as low as 0.0410 μg/kg, and the recovery was 94.83% ~ 108.24%. Therefore, this label-free SERS sensor offers a rapid and sensitive approach for the trace detection of florfenicol residues in food safety monitoring.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":705,\"journal\":{\"name\":\"Microchimica Acta\",\"volume\":\"192 4\",\"pages\":\"\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-03-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s00604-025-07076-2.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microchimica Acta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00604-025-07076-2\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchimica Acta","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00604-025-07076-2","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Optimal bimetallic Au@Ag nanocuboids-based SERS sensor for label-free ultrasensitive detection of florfenicol residue in eggs
A label-free surface-enhanced Raman scattering (SERS) sensor using optimal bimetallic Au@Ag nanocuboids (Au@Ag NCs) was developed for ultrasensitive detection of florfenicol residue in eggs. The Raman characteristic peaks of florfenicol detection were identified at 1145 cm−1 and 1595 cm−1 which were consistent with the theoretical Raman spectrum of florfenicol calculated by density functional theory. The Au@Ag NCs were optimized by changing the aspect ratio of Au nanorods and the thickness of Ag nanocuboids, achieving an enhancement factor of 1.69 × 106 for SERS signals. Under optimal conditions, the label-free SERS sensor demonstrated a broad linear range of 0.01 mg/kg to 100 mg/kg for florfenicol in real sample. The limit of detection of florfenicol in eggs was as low as 0.0410 μg/kg, and the recovery was 94.83% ~ 108.24%. Therefore, this label-free SERS sensor offers a rapid and sensitive approach for the trace detection of florfenicol residues in food safety monitoring.
期刊介绍：
As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.
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