通过铜介导的 2-芳基苯并咪唑 C-H 异氰酸化合成苯并咪唑并[1,2-c]喹唑啉-6(5H)-酮衍生物

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-03 DOI:10.1016/j.tet.2025.134569

Ali Nasirpour, Zarrin Ghasemi

引用次数: 0

摘要

公开了一种利用原子经济型C-H官能化方法合成苯并咪唑[1,2-c]喹唑啉-6(5H)- 1的高效方案。铜介导的2-芳基苯并咪唑衍生物的芳基环异氰化，再进行分子内环化反应得到所需产物。我们对产品进行了多样化和纯化，无需色谱法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of benzimidazo[1,2-c]quinazolin-6(5H)-one derivatives via copper-mediated C–H isocyanatation of 2-arylbenzimidazoles

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Synthesis of benzimidazo[1,2-c]quinazolin-6(5H)-one derivatives via copper-mediated C–H isocyanatation of 2-arylbenzimidazoles

An efficient protocol is disclosed for the synthesis of benzimidazo[1,2-c]quinazolin-6(5H)-ones utilizing an atom-economical C–H functionalization method. Copper-mediated isocyanatation of the aryl ring of the prepared 2-arylbenzimidazole derivatives, followed with intramolecular cyclization reaction resulted in the desired products. We diversified and purified the products without chromatography.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.