艾滋病毒感染者接受一年抗逆转录病毒治疗后血脂变化——免疫参数的意义

IF 1.5 Q4 INFECTIOUS DISEASES

IJID regions Pub Date : 2025-03-01 DOI:10.1016/j.ijregi.2025.100602

Agnieszka Lembas , Andrzej Załęski , Tomasz Mikuła , Joanna Kozłowska , Alicja Wiercińska-Drapało

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引用次数: 0

摘要

目的本研究旨在分析HIV感染者的脂质特征，并观察1年抗逆转录病毒治疗（ART）期间脂质参数的变化，特别是免疫参数的变化。方法我们分析了刚确诊的成年HIV感染者（PWH），他们开始抗逆转录病毒治疗，持续不间断治疗1年，并实现了完全的病毒抑制。患者未接受降脂治疗。在艾滋病诊断时和抗逆转录病毒治疗12个月后检测分化簇（CD4）计数、CD4:CD8比值、HIV 1型病毒载量和脂质谱。结果共纳入70例患者。在ART治疗1年后，观察到总胆固醇、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）显著增加，甘油三酯浓度下降。基线CD4计数<；200/µl与较高的基线LDL胆固醇相关（P = 0.036），女性与总胆固醇、LDL和非hdl胆固醇升高相关(P = 0.005；P = 0.011；P = 0.008)。基线CD4计数为200/µl的患者的总胆固醇、低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇均显著升高(P = 0.033；P = 0.009；P = 0.009)和甘油三酯（P = 0.003）水平低于CD4水平≥200/µl的患者。结论所有接受抗逆转录病毒治疗的PWH患者应定期评估血脂参数，特别是基线CD4计数≤200/µl的患者。

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Changes in the lipid profile in people with HIV after one year of antiretroviral therapy – the significance of immune parameters

Objectives

This study aimed to analyze lipid profiles among people with HIV and observe changes in lipid parameters during 1 year of antiretroviral therapy (ART), with particular reference to immune parameters.

Methods

We analyzed adult newly diagnosed people with HIV (PWH) who started ART, continued uninterruptedly for 1 year and achieved complete viral suppression. Patients were not receiving lipid-lowering therapy. The cluster of differentiation (CD4) count, CD4:CD8 ratio, HIV type 1 viral load, and lipid profile were examined at HIV diagnosis and after 12 months of ART.

Results

The study included 70 patients. Significant increases in total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol and decreases in triglyceride concentrations after 1 year of ART were observed. A baseline CD4 count <200/µl was associated with higher baseline LDL cholesterol (P = 0.036), and female sex with elevated total, LDL, and non-HDL cholesterol (P = 0.005; P = 0.011; P = 0.008). Patients with baseline CD4 counts <200/µl had significantly higher total, LDL, and non-HDL cholesterol (P = 0.033; P = 0.009; P = 0.009) and triglyceride (P = 0.003) levels after 1 year of ART than patients with CD4 levels ≥200/µl.