弗雷明汉心脏研究中OCT血管造影衍生视网膜毛细血管灌注测量

IF 3.2 Q1 OPHTHALMOLOGY

Ophthalmology science Pub Date : 2024-12-27 DOI:10.1016/j.xops.2024.100696

Ana D. Collazo Martinez BS , Shu Jie Ting MA , Anoush Shahidzadeh MPH , Brinda Vaidya BS , Tim Kowalczyk MBA , Muhammed Alluwimi PhD , Sujata Rijal PhD , Xuejuan Jiang PhD , Ruikang Wang PhD , Alexa Beiser PhD , Lucia Sobrin MD, MPH , Sudha Seshadri MD, DM , Amir H. Kashani MD, PhD

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引用次数: 0

摘要

目的报告Framingham心脏研究（FHS）中视网膜灌注的基线人口统计学关联和新的眼间相关性。DesignCross-sectional研究。参与者：共招募了11800名参与者。其中962名参与者（平均年龄75±7岁，59%为女性，1720只未扩张眼）有OCT血管造影（OCTA）数据。方法于2020年至2022年从社区FHS中招募参与者。采用中央凹中心3 × 3 mm2 OCTA扫描无创测量每位受试者双眼未扩张的视网膜毛细血管灌注。计算视网膜浅层、深层和全视网膜厚度的血管骨架密度（VSD）、血管面积密度（VAD）和通量等视网膜毛细血管灌注测量。使用多变量混合效应模型来检验视网膜灌注测量与眼睛偏侧性、性别、图像质量、眼轴长度（AL）和年龄之间的关系。评估个体参与者两眼视网膜灌注测量的相关性。主要观察指标：血管骨架密度、VAD和血流。结果1244只眼（73%）有可用的OCTA数据，其中52%来自右眼。尽管个体的两只眼睛之间视网膜灌注测量有显著的相关性，但这只是中等程度的相关性(R = 0.6, P <；0.000)。随着年龄的增长，视网膜灌注也显著减少(P <；0.001)，在控制了性别、图像质量、眼侧度和AL后，发现年龄和层特异性视网膜灌注之间存在潜在的相互作用（P = 0.058）。所有视网膜灌注测量（VAD、VSD和通量）均观察到类似的结果。投影伪影去除占9%到34% (P <；0.050)对DRL毛细血管灌注指标变化的影响。结论在校正图像质量和扫描水平伪影后，个体两眼间的视网膜毛细血管灌注测量仅具有中度相关性。这对研究设计和解释单方视网膜循环研究的数据具有重要意义。这些数据表明眼间视网膜灌注差异有生理和疾病相关的原因，值得进一步研究。财务披露专有或商业披露可在本文末尾的脚注和披露中找到。

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OCT Angiography-Derived Retinal Capillary Perfusion Measures in the Framingham Heart Study

Purpose

To report baseline demographic associations and novel intereye correlations of retinal perfusion in the Framingham Heart Study (FHS).

Design

Cross-sectional study.

Participants

One thousand eighteen participants were recruited. Of these, 962 participants (mean age 75 ± 7, 59% female, 1720 undilated eyes) had any OCT angiography (OCTA) data.

Methods

Participants from the community-based FHS were recruited between 2020 and 2022. Foveal-centered 3 × 3 mm² OCTA scans were used to noninvasively measure retinal capillary perfusion in both undilated eyes of each subject. Retinal capillary perfusion measures, including vessel skeleton density (VSD), vessel area density (VAD), and flux, were calculated in the superficial retinal layer, deep retinal layer (DRL), and full retinal thickness. Multivariate mixed-effect models were used to examine the association between retinal perfusion measures and eye laterality, sex, image quality, axial length (AL), and age. Correlation of retinal perfusion measures between 2 eyes of individual participants was assessed.

Main Outcome Measures

Vessel skeleton density, VAD, and flux.

Results

One thousand two hundred forty-four eyes (73%) had usable OCTA data with 52% acquired from the right eye. Although there was a significant correlation of retinal perfusion measures between 2 eyes of an individual, this was only moderate in magnitude (R = 0.6, P < 0.000). There was also a significant decrease in retinal perfusion with age (P < 0.001) after controlling for sex, image quality, eye laterality, and AL. A potential interaction between age and layer-specific retinal perfusion was found (P = 0.058). Similar findings were observed with all measures of retinal perfusion (VAD, VSD, and flux). Projection artifact removal accounted for 9% to 34% (P < 0.050) of the variation in capillary perfusion measures in the DRL.

Conclusions

Retinal capillary perfusion measures between 2 eyes of an individual share only moderate correlation even after adjusting for image quality and scan level artifacts. This has important implications in study design and interpretation of data from unilaterally performed studies on the retinal circulation. These data suggest that intereye differences in retinal perfusion have physiological and disease-related causes that warrant further investigation.