双相情感障碍中炎症标志物的性别差异

Q3 Psychology

Journal of Affective Disorders Reports Pub Date : 2025-02-19 DOI:10.1016/j.jadr.2025.100892

Yanlin Liu , Hui Xin Ng , Ashley Sutherland , Soohyun Joe , Benchawanna Soontornniyomkij , Federica Klaus , Lisa T. Eyler

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引用次数: 0

摘要

慢性外周和脑炎症过程有助于情绪障碍。炎症升高可能是双相情感障碍（BD）的生物标志物。研究注意到一般人群中炎症标志物水平的性别差异，主要集中在手术或感染的影响上。我们探讨了四种炎症标志物——IL-6、TNF-α、CCL-11和CRP——在BD患者和健康对照组（HC）参与者中男女血清水平的差异，并比较了组间的性别差异。方法156名参与者(HC：女性49人，男性45人；BD: 38名女性，24名男性)在一项关于BD炎症和认知衰老的纵向研究中平均进行了三次基线访问。在两周的时间里，每周收集血液样本，并使用电化学发光法评估生物标志物水平。采用一般线性模型，以吸烟、BMI和年龄为协变量，考察性别、诊断组和性别x诊断组对IL-6、TNF-α、CCL-11和CRP的主要影响。结果BD组患者IL-6水平高于HC组。性别、诊断组及其相互作用对肿瘤坏死因子α (TNF-α)有影响，双相障碍男性患者水平较高，HC女性患者水平较低。男性的CCL-11高于女性。BD男性CRP水平高于HC男性。结论男性血清TNF-α水平高于女性；这种差异在BD中比HC更为明显。与HC男性相比，BD患者CRP升高。未来的抗炎治疗应考虑双相障碍可能存在的性别差异。

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Sex differences in inflammatory markers in bipolar disorder

Background

Chronic peripheral and brain inflammatory processes contribute to mood disorders. Elevated inflammation may serve as a biomarker for bipolar disorder (BD). Studies have noted sex differences in inflammatory marker levels in the general population, primarily focusing on the effects of surgeries or infections. We explored differences between men and women in serum levels of four inflammatory markers – IL-6, TNF-α, CCL-11, and CRP – among individuals with BD and healthy comparison (HC) participants and compared sex differences between groups.

Methods

Data from 156 participants (HC: 49 women, 45 men; BD: 38 women, 24 men) were averaged over three baseline visits of a longitudinal study on inflammation and cognitive aging in BD. Blood samples were collected every week during a two-week period and assessed for biomarker levels using electrochemiluminescence assays. General linear models were applied to examine the main effects of sex, diagnostic group, and sex x diagnostic group for IL-6, TNF-α, CCL-11, and CRP, with smoking, BMI, and age included as covariates.

Results

Participants with BD showed higher levels of IL-6 than HC. Sex, diagnostic group, and their interaction showed effects in TNF-α, with higher levels in men with BD and lower levels in HC women. CCL-11 was higher in men than women. CRP levels were higher in BD men than HC men.

Conclusions

Men had higher TNF-α serum levels than women; this difference was more pronounced in BD than HC. CRP was elevated in BD compared to HC men. Future anti-inflammatory treatments should consider possible sex differences in BD.

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