高海拔暴露后健康成人眼底变化

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-03-01 DOI:10.1016/j.pdpdt.2025.104542

Jiaxin Li , Yunzhu Kong , Peiyu Wang , Chen Chen, Juping Liu, Xiaorong Li, Yan Shao

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引用次数: 0

摘要

背景：量化健康成人眼底长期高海拔（HA）暴露的变化。目的为高原眼病的防治提供参考。方法：选取15名健康高海拔暴露者30只眼作为研究对象。扫描源光学相干断层扫描/扫描源光学相干断层扫描血管造影（SS-OCT/SS-OCTA）用于分析平台暴露前后受试者眼底变化。眼底指标包括黄斑各象限的最佳矫正视力（BCVA）、视网膜厚度（ReT）、内层ReT、外层ReT、神经纤维层厚度（RNFLT）、神经节细胞内丛状层厚度（GCIPLT）、血管密度（VD）、灌注区大小（PA）、脉络膜血管体积（CVV）、脉络膜血管指数（CVI）。所有指标均采用广义估计方程（GEE）进行分析。结果：与基线数据相比，所有高海拔工作1年以上的参与者的视力没有变化（P>0.05），所有象限的ReT、Outer ReT、GCIPLT和VD均下降（P>0.05）。Inner ReT和RNFLT呈上升趋势（P < 0.05）。PA在全视网膜、内视网膜、浅毛细血管丛（SCP）和中毛细血管丛（ICP）均显著升高(p)。结论：高海拔暴露引起的全身适应性改变可引起不同程度的眼底结构和功能改变。目前的研究结果需要大规模的纵向研究来获得关于这一主题的更明确的数据。

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Fundus changes in healthy adults after high altitude exposure

Background

To quantify the changes of long-term high altitude (HA) exposure of fundus in healthy adults. The aim is to provide a reference for the prevention and treatment of high altitude ophthalmopathy.

Methods

30 eyes of 15 healthy participants exposed to high altitude were recruited in this study. Swept-source optical coherence tomography/Swept-source optical coherence tomography angiography (SS-OCT/SS-OCTA) was used to analyze fundus changes in participants before and after plateau exposure. Fundus metrics included best corrected visual acuity (BCVA), the thickness of the retina (ReT), Inner ReT, Outer ReT, nerve fiber layer thickness (RNFLT), and ganglion cell internal plexiform layer thickness (GCIPLT), vascular density (VD), the size of the perfusion area (PA), choroidal vessel volume (CVV), and choroidal vascularity index (CVI) in all quadrants of the macula. All metrics were analyzed by generalized estimating equations (GEE).

Results

Compared with baseline data, all participants who worked at high altitude for more than one year showed no change in visual acuity (P > 0.05) and a decreased in ReT, Outer ReT, GCIPLT and VD in all quadrants (P > 0.05). In addition, Inner ReT and RNFLT show an upward trend (P > 0.05). PA was significantly increased in the overall retina, Inner retina, superficial capillary plexus (SCP), and middle capillary plexus (ICP) (P < 0.05).

Conclusion

The systemic adaptive changes due to high altitude exposure may cause varying degrees of structural and functional changes in the fundus. The current findings require large-scale longitudinal studies to obtain more definitive data on this topic.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.