{"title":"一种新的ArsR转录抑制因子控制罗氏砷杆菌SM-1抗砷操纵子的转录。","authors":"Yujie Zhang, Wenjun Wu, Ke Huang, Fang-Jie Zhao","doi":"10.1002/mlf2.12155","DOIUrl":null,"url":null,"abstract":"<p><p>Arsenic is the most common toxic metalloid in the environment. Nearly all organisms have genes for arsenic detoxification. Arsenic detoxification genes are frequently organized in chromosomal or plasmid-encoded arsenic resistance (<i>ars</i>) operons, which are commonly regulated by members of the ArsR transcriptional repressors. To date, three As(III)-responsive ArsRs with different As(III) binding sites have been identified. Here, we identify a new type of As(III)-responsive ArsR repressor that has an atypical As(III) binding site and controls transcription of the <i>ars</i> operon of <i>Arsenicibacter rosenii</i> SM-1. Our results provide new insights into the classification and evolution relationship of the ArsR transcriptional repressors.</p>","PeriodicalId":94145,"journal":{"name":"mLife","volume":"4 1","pages":"96-100"},"PeriodicalIF":4.5000,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868830/pdf/","citationCount":"0","resultStr":"{\"title\":\"A new type of ArsR transcriptional repressor controls transcription of the arsenic resistance operon of <i>Arsenicibacter rosenii</i> SM-1.\",\"authors\":\"Yujie Zhang, Wenjun Wu, Ke Huang, Fang-Jie Zhao\",\"doi\":\"10.1002/mlf2.12155\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Arsenic is the most common toxic metalloid in the environment. Nearly all organisms have genes for arsenic detoxification. Arsenic detoxification genes are frequently organized in chromosomal or plasmid-encoded arsenic resistance (<i>ars</i>) operons, which are commonly regulated by members of the ArsR transcriptional repressors. To date, three As(III)-responsive ArsRs with different As(III) binding sites have been identified. Here, we identify a new type of As(III)-responsive ArsR repressor that has an atypical As(III) binding site and controls transcription of the <i>ars</i> operon of <i>Arsenicibacter rosenii</i> SM-1. Our results provide new insights into the classification and evolution relationship of the ArsR transcriptional repressors.</p>\",\"PeriodicalId\":94145,\"journal\":{\"name\":\"mLife\",\"volume\":\"4 1\",\"pages\":\"96-100\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-01-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868830/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"mLife\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/mlf2.12155\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"mLife","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/mlf2.12155","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
A new type of ArsR transcriptional repressor controls transcription of the arsenic resistance operon of Arsenicibacter rosenii SM-1.
Arsenic is the most common toxic metalloid in the environment. Nearly all organisms have genes for arsenic detoxification. Arsenic detoxification genes are frequently organized in chromosomal or plasmid-encoded arsenic resistance (ars) operons, which are commonly regulated by members of the ArsR transcriptional repressors. To date, three As(III)-responsive ArsRs with different As(III) binding sites have been identified. Here, we identify a new type of As(III)-responsive ArsR repressor that has an atypical As(III) binding site and controls transcription of the ars operon of Arsenicibacter rosenii SM-1. Our results provide new insights into the classification and evolution relationship of the ArsR transcriptional repressors.