一种新的ArsR转录抑制因子控制罗氏砷杆菌SM-1抗砷操纵子的转录。

IF 4.5 Q1 MICROBIOLOGY
mLife Pub Date : 2025-01-19 eCollection Date: 2025-02-01 DOI:10.1002/mlf2.12155
Yujie Zhang, Wenjun Wu, Ke Huang, Fang-Jie Zhao
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引用次数: 0

摘要

砷是环境中最常见的有毒类金属。几乎所有的生物体都有砷解毒的基因。砷解毒基因通常组织在染色体或质粒编码的砷抗性(ars)操纵子中,这些操纵子通常由砷抗性转录抑制子的成员调节。迄今为止,已经鉴定出三个具有不同As(III)结合位点的As(III)响应ArsRs。在这里,我们发现了一种新的As(III)响应型ArsR抑制因子,它具有非典型的As(III)结合位点,并控制rosenii Arsenicibacter SM-1的ars操纵子的转录。我们的研究结果为研究ArsR转录抑制因子的分类和进化关系提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A new type of ArsR transcriptional repressor controls transcription of the arsenic resistance operon of Arsenicibacter rosenii SM-1.

Arsenic is the most common toxic metalloid in the environment. Nearly all organisms have genes for arsenic detoxification. Arsenic detoxification genes are frequently organized in chromosomal or plasmid-encoded arsenic resistance (ars) operons, which are commonly regulated by members of the ArsR transcriptional repressors. To date, three As(III)-responsive ArsRs with different As(III) binding sites have been identified. Here, we identify a new type of As(III)-responsive ArsR repressor that has an atypical As(III) binding site and controls transcription of the ars operon of Arsenicibacter rosenii SM-1. Our results provide new insights into the classification and evolution relationship of the ArsR transcriptional repressors.

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2.30
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