单次伽玛感觉刺激包含实时脑电图,但不增强知觉、注意力、短期记忆或长期记忆。

IF 2.8 Q2 NEUROSCIENCES
Journal of Alzheimer's disease reports Pub Date : 2025-01-13 eCollection Date: 2025-01-01 DOI:10.1177/25424823241311927
Cai-Syuan Wu, Ting-Xuan Lin, Yu-Hui Lo, Shih-Chiang Ke, Prangya Parimita Sahu, Philip Tseng
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引用次数: 0

摘要

背景:研究表明,伽马(40hz)视听刺激可以增强阿尔茨海默病患者的伽马振荡并改善其认知功能。然而,尽管有很好的长期效果,短期或单次40赫兹的人类干扰的有效性受到了行为研究的质疑,这些研究未能发现可观察到的认知后遗症,原因可能有两个:1)缺乏验证的伽马神经夹带,因为大多数研究缺乏并发脑电图(EEG)数据来验证伽马神经夹带确实发生了;2)缺乏多样化的认知测试,因为大多数研究没有测试广泛的认知因素。目的:本研究旨在提高检测单次伽马夹带的灵敏度。我们采用1)刺激中、刺激后脑电图监测,以确保娱乐有效;2)综合认知电池,探测感知、注意、工作记忆和长期记忆。方法:被试接受30 min的同步40 Hz光声刺激,随后进行视觉感知任务、注意网络任务、变化检测工作记忆任务和长期图像记忆任务,并发脑电图。结果:我们观察到在刺激过程中有明显的40 Hz脑电图带动,但刺激后没有明显的40 Hz振荡,也没有明显的认知改善。结论:尽管有强大的40赫兹在线夹带,伽玛感觉夹带需要持续的长期暴露来诱导认知和神经变化。未来的研究应确定40hz刺激的最佳持续时间和频率,以最大限度地发挥其治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Single-session gamma sensory stimulation entrains real-time electroencephalography but does not enhance perception, attention, short-term memory, or long-term memory.

Background: Studies have shown that gamma (40 Hz) audiovisual stimulation can enhance gamma oscillations and improve cognitive functioning in patients with Alzheimer's disease. However, despite promising long-term results, the efficacy of short-duration or single-session 40 Hz entrainment in humans has been questioned by behavioral studies that fail to find observable cognitive aftereffects, for two possible reasons: 1) lack of validated gamma entrainment, as most studies lacked concurrent electroencephalography (EEG) data to verify that gamma neural entrainment did take place, and 2) lack of diverse cognitive tests, as most studies did not test a wide range of cognitive factors.

Objective: This study aimed to increase sensitivity for detecting single-session gamma entrainment. We employed 1) mid- and post-stimulation EEG monitoring to ensure entrainment worked, and 2) a comprehensive cognitive battery that probes perception, attention, working memory, and long-term memory.

Methods: Participants received 30 min of synchronized 40 Hz light and sound stimulation, followed by a visual perceptual task, attentional network task, change detection working memory task, and long-term picture memory task, with concurrent EEG.

Results: We observed robust 40 Hz EEG entrainment during stimulation but no significant 40 Hz oscillation after stimulation, and no significant cognitive improvements.

Conclusions: Despite robust 40 Hz online entrainment, gamma sensory entrainment requires consistent long-term exposure to induce cognitive and neurological changes. Future research should determine the optimal duration and frequency of 40 Hz stimulation to maximize its therapeutic potential.

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