热休克蛋白70在阿尔茨海默病和其他痴呆症中的作用:一种可能的替代治疗方法。

IF 2.8 Q2 NEUROSCIENCES
Journal of Alzheimer's disease reports Pub Date : 2025-01-13 eCollection Date: 2025-01-01 DOI:10.1177/25424823241307021
Antonio Valle-Medina, Claudia Camelia Calzada-Mendoza, María Esther Ocharan-Hernández, Carlos Alberto Jiménez-Zamarripa, Teresa Juárez-Cedillo
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引用次数: 0

摘要

阿尔茨海默病(AD)被认为是一个全球性的健康问题,由于它导致患者残疾的程度,它给社会带来了沉重的负担。在缺乏这种疾病的治疗替代方案的情况下,我们将遵循与分子伴侣相关的AD发展的生化途径之一。这些分子在大脑层面负责清除毒素和错误折叠的蛋白质。这些伴侣蛋白是热休克蛋白(HSPs)家族的一组蛋白质,在它们的功能中,帮助维持体内平衡和保护细胞免受压力。许多作者已经描述了热休克蛋白在不同神经退行性疾病中的活性,强调了热休克蛋白70 (HSP70)在神经退行性疾病特征异常蛋白(如淀粉样蛋白-β (Aβ)和tau)存在时的活性。HSP70在AD和其他痴呆症中的作用在于其机制,它与HSP家族的其他蛋白一起具有通过促进催化途径消除Aβ聚集的能力。在这篇综述中,我们探讨了HSP70蛋白在阿尔茨海默病和其他痴呆症中的生物学作用及其潜在的治疗应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Heat shock protein 70 in Alzheimer's disease and other dementias: A possible alternative therapeutic.

Alzheimer's disease (AD) is considered a global health issue with a high social burden due to the level of disability it causes in those who suffer from it. In the absence of a therapeutic alternative for this disease, we will follow one of the biochemical pathways involved in the development of AD, which is related to molecular chaperones. The molecules are responsible for eliminating toxins and misfolded proteins at the cerebral level. These chaperones are a set of proteins from the heat shock proteins (HSPs) family, which, among their functions, help maintain homeostasis and protect cells against stress. Various authors have described the activity of HSPs in different neurodegenerative diseases, highlighting the activity of heat shock protein 70 (HSP70) in the presence of aberrant proteins characteristic of neurodegeneration, such as amyloid-β (Aβ) and tau. The role of HSP70 in AD and other dementias lies in its mechanism, which, along with other proteins from the HSP family, has the capacity to eliminate Aβ aggregates by promoting catalytic pathways. In this review, we explore the biological role of the HSP70 protein in AD and other dementias and its potential therapeutic use.

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