Jonathan Fernando Cubas Guillen, Carolina Agata Ardohain Cristalli, Waleska Berrios, Florencia Deschle, Guido Dorman, Julian Fernandez Boccazzi, Ignacio Flores, Héctor Gastón Graviotto, Cristian Flavio Isaac, Galeno Rojas, Karen Daniela Román, Maria de la Paz Scribano Parada, Marcos Sorbara, Ricardo F Allegri, Ismael Luis Calandri
{"title":"快速进展性痴呆的病因学：全球和拉丁美洲原因的系统回顾和荟萃分析。","authors":"Jonathan Fernando Cubas Guillen, Carolina Agata Ardohain Cristalli, Waleska Berrios, Florencia Deschle, Guido Dorman, Julian Fernandez Boccazzi, Ignacio Flores, Héctor Gastón Graviotto, Cristian Flavio Isaac, Galeno Rojas, Karen Daniela Román, Maria de la Paz Scribano Parada, Marcos Sorbara, Ricardo F Allegri, Ismael Luis Calandri","doi":"10.1177/25424823251314505","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Rapidly progressive dementia (RPD) is a group of neurological diseases, where three etiologies are particularly relevant: neurodegenerative, prion and autoimmune encephalitis (AIE) diseases.</p><p><strong>Objective: </strong>The aim of this study is to conduct a systematic review and meta-analysis of the frequency of these etiologies causing RPD in worldwide and Latin America (LatAm).</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted. A bibliographic search of publications related to the etiologies of RPD was done. The etiologies, the timeframe definition (<1 year versus <2 years) and the study's place of origin were analyzed.</p><p><strong>Results: </strong>A total of 10 articles were selected for the analysis in this study (n = 1006 patients). Three studies were originated in LatAm cohorts (two from Argentina and one from Brazil). The global prevalence of RPD due to neurodegenerative disease was 23% CI95% [11%; 42%]; prion diseases, 16% CI95% [9%; 28%]; and AIE, 12% CI95% [6%; 22%]. Comparing each overall proportion of etiologies of LatAm versus non-LatAm there were statistically significant differences for AIE (25% versus 8%, respectively, <i>p </i>< 0.01). In the case of timeframe definitions, the comparison of the etiological percentage did not show statistically significant differences.</p><p><strong>Conclusions: </strong>From our results, approximately a half of the causes of RPD were due to neurodegenerative, prion, and AIE diseases. Future studies will be needed to analyze this issue both globally and regionally.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251314505"},"PeriodicalIF":2.8000,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864264/pdf/","citationCount":"0","resultStr":"{\"title\":\"Etiologies of rapidly progressive dementias: A systematic review and meta-analysis of causes in worldwide and Latin America.\",\"authors\":\"Jonathan Fernando Cubas Guillen, Carolina Agata Ardohain Cristalli, Waleska Berrios, Florencia Deschle, Guido Dorman, Julian Fernandez Boccazzi, Ignacio Flores, Héctor Gastón Graviotto, Cristian Flavio Isaac, Galeno Rojas, Karen Daniela Román, Maria de la Paz Scribano Parada, Marcos Sorbara, Ricardo F Allegri, Ismael Luis Calandri\",\"doi\":\"10.1177/25424823251314505\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Rapidly progressive dementia (RPD) is a group of neurological diseases, where three etiologies are particularly relevant: neurodegenerative, prion and autoimmune encephalitis (AIE) diseases.</p><p><strong>Objective: </strong>The aim of this study is to conduct a systematic review and meta-analysis of the frequency of these etiologies causing RPD in worldwide and Latin America (LatAm).</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted. A bibliographic search of publications related to the etiologies of RPD was done. The etiologies, the timeframe definition (<1 year versus <2 years) and the study's place of origin were analyzed.</p><p><strong>Results: </strong>A total of 10 articles were selected for the analysis in this study (n = 1006 patients). Three studies were originated in LatAm cohorts (two from Argentina and one from Brazil). The global prevalence of RPD due to neurodegenerative disease was 23% CI95% [11%; 42%]; prion diseases, 16% CI95% [9%; 28%]; and AIE, 12% CI95% [6%; 22%]. Comparing each overall proportion of etiologies of LatAm versus non-LatAm there were statistically significant differences for AIE (25% versus 8%, respectively, <i>p </i>< 0.01). In the case of timeframe definitions, the comparison of the etiological percentage did not show statistically significant differences.</p><p><strong>Conclusions: </strong>From our results, approximately a half of the causes of RPD were due to neurodegenerative, prion, and AIE diseases. Future studies will be needed to analyze this issue both globally and regionally.</p>\",\"PeriodicalId\":73594,\"journal\":{\"name\":\"Journal of Alzheimer's disease reports\",\"volume\":\"9 \",\"pages\":\"25424823251314505\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-01-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864264/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Alzheimer's disease reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/25424823251314505\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's disease reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/25424823251314505","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Etiologies of rapidly progressive dementias: A systematic review and meta-analysis of causes in worldwide and Latin America.
Background: Rapidly progressive dementia (RPD) is a group of neurological diseases, where three etiologies are particularly relevant: neurodegenerative, prion and autoimmune encephalitis (AIE) diseases.
Objective: The aim of this study is to conduct a systematic review and meta-analysis of the frequency of these etiologies causing RPD in worldwide and Latin America (LatAm).
Methods: A systematic review and meta-analysis were conducted. A bibliographic search of publications related to the etiologies of RPD was done. The etiologies, the timeframe definition (<1 year versus <2 years) and the study's place of origin were analyzed.
Results: A total of 10 articles were selected for the analysis in this study (n = 1006 patients). Three studies were originated in LatAm cohorts (two from Argentina and one from Brazil). The global prevalence of RPD due to neurodegenerative disease was 23% CI95% [11%; 42%]; prion diseases, 16% CI95% [9%; 28%]; and AIE, 12% CI95% [6%; 22%]. Comparing each overall proportion of etiologies of LatAm versus non-LatAm there were statistically significant differences for AIE (25% versus 8%, respectively, p < 0.01). In the case of timeframe definitions, the comparison of the etiological percentage did not show statistically significant differences.
Conclusions: From our results, approximately a half of the causes of RPD were due to neurodegenerative, prion, and AIE diseases. Future studies will be needed to analyze this issue both globally and regionally.
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