运动与认知健康的关系:APOE ε4状态的分层分析。

IF 2.8 Q2 NEUROSCIENCES
Journal of Alzheimer's disease reports Pub Date : 2024-11-24 eCollection Date: 2024-01-01 DOI:10.1177/25424823241290528
Yeonjung Jane Lee, Ernest Gonzales, Yanyan Wu, Kathryn L Braun, Peter Martin, Bradley Willcox, Ross Andel
{"title":"运动与认知健康的关系:APOE ε4状态的分层分析。","authors":"Yeonjung Jane Lee, Ernest Gonzales, Yanyan Wu, Kathryn L Braun, Peter Martin, Bradley Willcox, Ross Andel","doi":"10.1177/25424823241290528","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Despite the growing evidence on the modifiable and genetic factors associated with cognitive health, little is known about the role of the apolipoprotein E (<i>APOE</i>) gene ε4 allele in the associations between productive or leisure activities and cognitive health.</p><p><strong>Objective: </strong>This study fills a gap of knowledge by examining the associations among employment, civic engagement, and leisure activities and cognitive health by the presence of <i>APOE</i> ε4 allele, an established risk factor of Alzheimer's disease (AD).</p><p><strong>Methods: </strong>Using pooled data from the Health and Retirement Study (HRS) Psychosocial and Lifestyle Questionnaires (2010-2016) and the HRS data on <i>APOE</i> ε4 alleles, linear regression models with a lagged dependent variable were performed to examine associations between productive or leisure activities and cognitive functioning at the follow-up time point, as well as the role of <i>APOE</i> ε4 in these associations.</p><p><strong>Results: </strong>Among all participants, employment, low or high-intensity volunteering, and cognitive/social leisure activities were associated with higher levels of cognitive functioning. The presence of at least one ε4 allele was related to poorer cognitive functioning at the follow-up time point. Among people without the <i>APOE</i> ε4 allele, employment, high-intensity volunteering, and cognitive/social leisure activities were significantly associated with cognitive functioning. Among people with at least one <i>APOE</i> ε4 allele, low-intensity volunteering and cognitive/physical leisure activities were significantly associated with better cognitive functioning.</p><p><strong>Conclusions: </strong>We found that employment, civic engagement, and leisure activities all contribute to cognitive health, although the benefits may be restricted to low-intensity volunteering and cognitive/physical leisure activities among individuals with at least one <i>APOE</i> ε4 allele, who are known to be inherently at a greater risk of AD, highlighting an avenue to a relatively easily implementable strategy to promote cognitive health in this subpopulation.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"8 1","pages":"1502-1515"},"PeriodicalIF":2.8000,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863737/pdf/","citationCount":"0","resultStr":"{\"title\":\"The association between activities and cognitive health: Stratified analysis by <i>APOE</i> ε4 status.\",\"authors\":\"Yeonjung Jane Lee, Ernest Gonzales, Yanyan Wu, Kathryn L Braun, Peter Martin, Bradley Willcox, Ross Andel\",\"doi\":\"10.1177/25424823241290528\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Despite the growing evidence on the modifiable and genetic factors associated with cognitive health, little is known about the role of the apolipoprotein E (<i>APOE</i>) gene ε4 allele in the associations between productive or leisure activities and cognitive health.</p><p><strong>Objective: </strong>This study fills a gap of knowledge by examining the associations among employment, civic engagement, and leisure activities and cognitive health by the presence of <i>APOE</i> ε4 allele, an established risk factor of Alzheimer's disease (AD).</p><p><strong>Methods: </strong>Using pooled data from the Health and Retirement Study (HRS) Psychosocial and Lifestyle Questionnaires (2010-2016) and the HRS data on <i>APOE</i> ε4 alleles, linear regression models with a lagged dependent variable were performed to examine associations between productive or leisure activities and cognitive functioning at the follow-up time point, as well as the role of <i>APOE</i> ε4 in these associations.</p><p><strong>Results: </strong>Among all participants, employment, low or high-intensity volunteering, and cognitive/social leisure activities were associated with higher levels of cognitive functioning. The presence of at least one ε4 allele was related to poorer cognitive functioning at the follow-up time point. Among people without the <i>APOE</i> ε4 allele, employment, high-intensity volunteering, and cognitive/social leisure activities were significantly associated with cognitive functioning. Among people with at least one <i>APOE</i> ε4 allele, low-intensity volunteering and cognitive/physical leisure activities were significantly associated with better cognitive functioning.</p><p><strong>Conclusions: </strong>We found that employment, civic engagement, and leisure activities all contribute to cognitive health, although the benefits may be restricted to low-intensity volunteering and cognitive/physical leisure activities among individuals with at least one <i>APOE</i> ε4 allele, who are known to be inherently at a greater risk of AD, highlighting an avenue to a relatively easily implementable strategy to promote cognitive health in this subpopulation.</p>\",\"PeriodicalId\":73594,\"journal\":{\"name\":\"Journal of Alzheimer's disease reports\",\"volume\":\"8 1\",\"pages\":\"1502-1515\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-11-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863737/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Alzheimer's disease reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/25424823241290528\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's disease reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/25424823241290528","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

背景:尽管越来越多的证据表明与认知健康相关的可改变因素和遗传因素,但载脂蛋白E (APOE)基因ε4等位基因在生产或休闲活动与认知健康之间的关系中所起的作用知之甚少。目的:通过APOE ε4等位基因的存在,探讨就业、公民参与、休闲活动与认知健康之间的关系,填补这一认知空白。APOE ε4等位基因是阿尔茨海默病(AD)的已知危险因素。方法:利用2010-2016年健康与退休研究(Health and Retirement Study, HRS)社会心理和生活方式问卷的汇总数据和APOE ε4等位基因的HRS数据,采用带滞后因变量的线性回归模型,研究在随访时间点生产或休闲活动与认知功能之间的关系,以及APOE ε4在这些关系中的作用。结果:在所有参与者中,就业、低强度或高强度志愿服务以及认知/社会休闲活动与较高水平的认知功能相关。至少一个ε4等位基因的存在与随访时间点较差的认知功能有关。在没有APOE ε4等位基因的人群中,就业、高强度志愿服务和认知/社会休闲活动与认知功能显著相关。在至少有一个APOE ε4等位基因的人群中,低强度的志愿活动和认知/体育休闲活动与更好的认知功能显著相关。结论:我们发现,就业、公民参与和休闲活动都有助于认知健康,尽管其益处可能仅限于低强度的志愿活动和认知/身体休闲活动,这些人至少有一个APOE ε4等位基因,已知其固有的AD风险更高,这突出了促进该亚人群认知健康的相对容易实施的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The association between activities and cognitive health: Stratified analysis by APOE ε4 status.

Background: Despite the growing evidence on the modifiable and genetic factors associated with cognitive health, little is known about the role of the apolipoprotein E (APOE) gene ε4 allele in the associations between productive or leisure activities and cognitive health.

Objective: This study fills a gap of knowledge by examining the associations among employment, civic engagement, and leisure activities and cognitive health by the presence of APOE ε4 allele, an established risk factor of Alzheimer's disease (AD).

Methods: Using pooled data from the Health and Retirement Study (HRS) Psychosocial and Lifestyle Questionnaires (2010-2016) and the HRS data on APOE ε4 alleles, linear regression models with a lagged dependent variable were performed to examine associations between productive or leisure activities and cognitive functioning at the follow-up time point, as well as the role of APOE ε4 in these associations.

Results: Among all participants, employment, low or high-intensity volunteering, and cognitive/social leisure activities were associated with higher levels of cognitive functioning. The presence of at least one ε4 allele was related to poorer cognitive functioning at the follow-up time point. Among people without the APOE ε4 allele, employment, high-intensity volunteering, and cognitive/social leisure activities were significantly associated with cognitive functioning. Among people with at least one APOE ε4 allele, low-intensity volunteering and cognitive/physical leisure activities were significantly associated with better cognitive functioning.

Conclusions: We found that employment, civic engagement, and leisure activities all contribute to cognitive health, although the benefits may be restricted to low-intensity volunteering and cognitive/physical leisure activities among individuals with at least one APOE ε4 allele, who are known to be inherently at a greater risk of AD, highlighting an avenue to a relatively easily implementable strategy to promote cognitive health in this subpopulation.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
2.80
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信