Hui-Fang Du, Lei Li, Ya-Hui Zhang, Xu Wang, Cheng-Yan Zhou, Hua-Jie Zhu, Charles U Pittman, Jia-Wen Shou, Fei Cao
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Interestingly, <b>1</b> and <b>2</b> displayed significant effects on the differentiation of 3T3-L1 adipocytes by down-regulating the expression of peroxisome proliferator-activated receptor gamma (PPAR<i>γ</i>) and CCAAT/enhancer binding protein alpha (C/EBP<i>α</i>) proteins, while monomers <b>3</b> and <b>4</b> exhibited no activity. Molecular docking results explained the mechanism that the interaction between dimer <b>1</b> and PPAR<i>γ</i> was stronger than that between monomer <b>3</b> and PPAR<i>γ</i>. Our research could provide new insight for the discovery of anti-obesity drugs.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s42995-024-00253-x.</p>","PeriodicalId":53218,"journal":{"name":"Marine Life Science & Technology","volume":"7 1","pages":"120-131"},"PeriodicalIF":5.8000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871200/pdf/","citationCount":"0","resultStr":"{\"title\":\"The first dimeric indole-diterpenoids from a marine-derived <i>Penicillium</i> sp. fungus and their potential for anti-obesity drugs.\",\"authors\":\"Hui-Fang Du, Lei Li, Ya-Hui Zhang, Xu Wang, Cheng-Yan Zhou, Hua-Jie Zhu, Charles U Pittman, Jia-Wen Shou, Fei Cao\",\"doi\":\"10.1007/s42995-024-00253-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Obesity has become a worldwide health problem. 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The first dimeric indole-diterpenoids from a marine-derived Penicillium sp. fungus and their potential for anti-obesity drugs.
Obesity has become a worldwide health problem. Seeking natural products with anti-obesity activity from lots of fungi has drawn the attention of pharmacologists. In our study, dipenipenoids A and B (1 and 2), the first dimeric indole-diterpenoids with a rare C-20-C-22' linkage, and their monomers (3 and 4), were isolated from a marine-derived Penicillium sp. CF-06 fungus from Suaeda salsa. The absolute configurations of 1-3 were assigned by the calculated TDDFT ECD method. The structure of 4 was verified by a single-crystal X-ray diffraction method for the first time. Interestingly, 1 and 2 displayed significant effects on the differentiation of 3T3-L1 adipocytes by down-regulating the expression of peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer binding protein alpha (C/EBPα) proteins, while monomers 3 and 4 exhibited no activity. Molecular docking results explained the mechanism that the interaction between dimer 1 and PPARγ was stronger than that between monomer 3 and PPARγ. Our research could provide new insight for the discovery of anti-obesity drugs.
Supplementary information: The online version contains supplementary material available at 10.1007/s42995-024-00253-x.
期刊介绍：
Marine Life Science & Technology (MLST), established in 2019, is dedicated to publishing original research papers that unveil new discoveries and theories spanning a wide spectrum of life sciences and technologies. This includes fundamental biology, fisheries science and technology, medicinal bioresources, food science, biotechnology, ecology, and environmental biology, with a particular focus on marine habitats.
The journal is committed to nurturing synergistic interactions among these diverse disciplines, striving to advance multidisciplinary approaches within the scientific field. It caters to a readership comprising biological scientists, aquaculture researchers, marine technologists, biological oceanographers, and ecologists.
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