灌注型超声造影评价软组织肿瘤恶性：附187例综合分析。

IF 3.1 3区医学 Q1 ACOUSTICS

Ultraschall in Der Medizin Pub Date : 2025-03-31 DOI:10.1055/a-2549-6101

Paul Mick, Katharina Sehmsdorf, Burkhard Lehner, Andreas Geisbüsch, Tobias Renkawitz, Mustafa Hariri, Julian Doll, Stefanos Tsitlakidis

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引用次数: 0

摘要

本研究旨在利用超声造影（CEUS）检查良性和恶性软组织肿瘤（STT）的灌注特征，并将STT微灌注与恶性肿瘤的关系联系起来。结果与患者特征、临床表现、MRI表现和组织病理学结果进行比较。方法本前瞻性单中心研究纳入了计划行STT活检的不明STT患者。临床评估和术前MRI与超声造影同时进行。进行灌注量化，计算灌注参数（峰值增强（Peak Enhancement， PE）、上升时间（Rise Time）、Wash-in灌注指数（Wash-in Perfusion Index）、Wash-out Rate）。比较不同STT灌注特性。结果187例患者纳入最终分析。良性STT和非良性STT的超声造影灌注有显著差异。非良性肿瘤的肿瘤灌注明显增加，半恶性、恶性和转移性stt的差异也显著。pe良性107.74 (34.65-345.62)；pe -半恶性166.06 (60.14-374.47)；pe恶性1042.24 (358.15-4917.74)；pe转移2632.37（2249.46-3788.94）。ROC分析显示，使用137的峰值增强临界值，恶性肿瘤检测的灵敏度为80%，PPV为69%。结论超声造影是除MRI外对STT进行初步评估的一种很有前途的工具。此外，它可以检测肿瘤组织内的重要区域，并可用于提高活检的准确性。[摘要]deutschel Es erfolte eine分析der Perfusionscharakteristika verschiedener gutartiger和bösartiger weichteiltumor (WTT) mittel kontrastverstärkten Ultraschalls （CEUS）。Die tumor - micro - perfusion wurde neben MRT-Bildgebung auch its den组织病理学（Befunden nach Biopsie korreliert, um Die prädiktive Qualität des CEUS zur präoperativen Diagnostik unklarer WTT zu untersuchen）。材料与方法：研究了两种不同类型的植物，分别为WTT和Biopsie inludiert。Klinische untersuchung and präoperative MRT-Bildgebung wurden durch eine CEUS-Untersuchung ergänzt。微灌注超声造影（CEUS）定量仪和灌注参数（峰值增强（PE）、上升时间、灌注冲洗指数和冲洗率）。[4] [endnoternoteristika verschiedener]。[j] [j] [j]。在良性WTT条件下，腹腔灌流参数在夜间良性WTT条件下也显著增加。恶性WTT、恶性WTT和转移性WTT在超声-微灌注下的特征[PE-Benigne， 2014,74 (34,65- 34,62)；pe -半恶性肿瘤，166 (6):14-374,47；pe - malignant 104,24 (35,15 -4917,74)；中国生物医学工程学报，2016,33(4):444 - 444。恶性肿瘤的检测方法研究[a]； [c]; [c]；Schlussfolgerungen CEUS erscheint als vielversprechendes Instrument zur wtt - diagnosis in Ergänzung zur MRT。darber hinaus kann es vitale Bereiche innerhalb eines WTT identifizien und so womöglich in Zukunft die Präzision einer offender ultraschallgest tzten Biopsie erhöhen。

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Perfusion-based malignancy assessment of soft-tissue tumors by contrast-enhanced ultrasound (CEUS): a comprehensive analysis of 187 cases.

This study aimed to examine the perfusion characteristics of benign and malignant soft-tissue tumors (STT) using contrast-enhanced ultrasound (CEUS) and to correlate STT micro-perfusion with malignancy. Findings were compared with patient characteristics, clinical presentations, MRI findings, and histopathological outcomes.This prospective single-center study involved patients with unclear STTs who were scheduled for STT biopsy. Clinical assessments and preoperative MRI were conducted along with CEUS. Perfusion quantification was performed, and perfusion parameters (peak enhancement [PE], rise time, wash-in perfusion index, and washout rate) were calculated. Perfusion characteristics of different STTs were compared.187 patients were included in the final analysis. Significant differences in CEUS perfusion between benign and non-benign STTs were demonstrated. Non-benign tumors showed significantly higher tumor perfusion and differences were also significant when comparing semi-malignant, malignant, and metastatic STTs. (PE-benign 107.74 [34.65-345.62]; PE-semi-malignant 166.06 [60.14-374.47]; PE-malignant 1042.24 [358.15-4917.74]; PE-metastasis 2632.37 [2249.46-3788.94]. ROC analysis demonstrated a sensitivity of 80% and a PPV of 69% for malignant tumor detection using a cut-off value for peak enhancement of 137 [a.u.].CEUS appears to be a promising tool for primary STT evaluation in addition to MRI. Furthermore, it can detect vital areas within the tumor tissue and could be utilized to increase biopsy accuracy.

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来源期刊

Ultraschall in Der Medizin 医学-核医学

CiteScore

5.30

自引率

8.80%

发文量

228

审稿时长

6-12 weeks

期刊介绍： Ultraschall in der Medizin / European Journal of Ultrasound publishes scientific papers and contributions from a variety of disciplines on the diagnostic and therapeutic applications of ultrasound with an emphasis on clinical application. Technical papers with a physiological theme as well as the interaction between ultrasound and biological systems might also occasionally be considered for peer review and publication, provided that the translational relevance is high and the link with clinical applications is tight. The editors and the publishers reserve the right to publish selected articles online only. Authors are welcome to submit supplementary video material. Letters and comments are also accepted, promoting a vivid exchange of opinions and scientific discussions.