泻心汤通过GPRs和hdac调节T2DM大鼠CD4+ T细胞的分化，恢复肠道屏障功能。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-09-02 DOI:10.1080/10286020.2025.2459603

Mei-Juan Liu , Yun Zhang , Ke Zhu , Wen-Wen Li , Chen Liu , Shu Jiang , Er-Xin Shang , Jin-Ao Duan

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引用次数: 0

摘要

本研究旨在从肠屏障功能角度探讨泻心汤改善2型糖尿病的潜在机制。结果表明，泻心汤能显著促进结肠上皮细胞GPRs的表达，同时抑制hdac的表达，进而显著提高TGF-β1和IL-18的水平，调节T细胞的分化，进一步维持肠道免疫稳态。同时，能明显抑制炎症信号通路，改善肠道屏障功能，缓解2型糖尿病。

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Xiexin Tang restores gut barrier function by regulating the differentiation of CD4+ T cells via GPRs and HDACs in T2DM rats

This study aimed to explore the potential mechanism of Xiexin Tang in improving type 2 diabetes mellitus from the perspective of intestinal barrier function. The results indicated that Xiexin Tang could notably promote the expression of GPRs while suppressing the expression of HDACs in colon epithelial cells, then significantly elevate the levels of TGF-β1 and IL-18 to regulate the differentiation of T cells and further maintain the intestinal immune homeostasis. Meanwhile, it could markedly inhibit the inflammatory signaling pathway to improve intestinal barrier function, relieving type 2 diabetes mellitus.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.