牛磺酸促进肠内分泌L细胞胰高血糖素样肽-1的分泌。

IF 3.5 4区生物学 Q1 Biochemistry, Genetics and Molecular Biology

FEBS Letters Pub Date : 2025-03-03 DOI:10.1002/1873-3468.70014

Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi

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引用次数: 0

摘要

牛磺酸是一种主要来源于食物的氨基磺酸，通过刺激胰腺β细胞分泌胰岛素来抑制血糖。然而，其与肠内分泌L细胞分泌胰高血糖素样肽-1 （GLP-1）的关系尚不清楚。本研究旨在确定牛磺酸在L细胞分泌GLP-1中的作用。牛磺酸可促进小鼠肠内分泌L细胞系GLUTag细胞分泌GLP-1，提高血浆GLP-1水平。通过牛磺酸转运体摄取牛磺酸增加细胞质内ATP水平，导致细胞内Ca2+浓度升高，并通过ATP敏感的K+通道关闭增强GLP-1分泌。这些发现可能有助于确定肥胖和饮食相关疾病预防的新治疗靶点。

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Taurine promotes glucagon-like peptide-1 secretion in enteroendocrine L cells.

Taurine, an amino-sulfonic acid mainly sourced from food, suppresses blood glucose by stimulating insulin secretion from pancreatic β-cells. However, its relationship with glucagon-like peptide-1 (GLP-1) secretion from enteroendocrine L cells is unclear. This study aimed to determine the role of taurine in GLP-1 secretion from L cells. Taurine administration promoted GLP-1 secretion in enteroendocrine L cell line GLUTag cells and increased plasma GLP-1 in mice. Taurine uptake via the taurine transporter increased cytosolic ATP levels, resulting in higher intracellular Ca²⁺ concentrations and enhanced GLP-1 secretion through ATP-sensitive K⁺ channel closure. These findings may help identify new therapeutic targets for obesity and diet-related disease prevention.

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来源期刊

FEBS Letters 生物-生化与分子生物学

CiteScore

7.00

自引率

2.90%

发文量

303

审稿时长

1.0 months

期刊介绍： FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.