显性极性对增强表现型和个性化治疗双相情感障碍:对最近发现的叙述性回顾。

IF 5.5 2区 医学 Q1 PSYCHIATRY
Giovanna Fico, Marta Bort, Meritxell Gonzalez-Campos, Giulia D'Alessandro, Michele De Prisco, Vincenzo Oliva, Gerard Anmella, Constanza Sommerhoff, Eduard Vieta, Andrea Murru
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引用次数: 0

摘要

综述目的:本文探讨了双相情感障碍(BD)的显性极性(PP),定义为在患者病程中躁狂或抑郁发作的优势。我们研究其临床相关性、神经生物学基础和指导个性化治疗策略的潜力。本综述旨在确定PP是否是一个可靠的病程指标,以及如何利用它来改善临床结果。最近的研究发现:PP对双相障碍的预后和治疗计划有显著影响。躁狂型和抑郁性PP与双相障碍不同的临床和神经生物学特征相关,而没有任何一种发作类型明显优势的个体代表了更严重的治疗亚组患者。极性指数(PI)的发展促进了基于PP的治疗决策。PP为精炼BD治疗和理解其复杂性提供了一个有价值的框架。未来的研究应侧重于细化PP定义,验证神经生物学标记,并将这些见解整合到综合治疗模型中,以改善患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predominant Polarity for Enhanced Phenotyping and Personalized Treatment of Bipolar Disorder: A Narrative Review on Recent Findings.

Purpose of review: This paper explores Predominant Polarity (PP) in Bipolar Disorder (BD), defined as the predominance of either manic or depressive episodes over a patient's course of illness. We examine its clinical relevance, neurobiological foundations, and potential for guiding personalized treatment strategies. The review seeks to determine whether PP is a reliable course specifier and how it can be utilized to improve clinical outcomes.

Recent findings: PP has a significant impact on prognosis and treatment planning in BD. Manic and depressive PP are associated with distinct clinical and neurobiological profiles of BD, while individuals without a clear predominance of either episode type represent a more severe to-treat subgroup of patients. The development of the Polarity Index (PI) facilitates treatment decisions based on PP. PP offers a valuable framework for refining BD treatment and understanding its complexity. Future research should focus on refining PP definitions, validating neurobiological markers, and integrating these insights into comprehensive treatment models to improve patient outcomes.

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来源期刊
CiteScore
11.30
自引率
3.00%
发文量
68
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published research in psychiatry. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by psychiatric disorders. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anxiety, medicopsychiatric disorders, and schizophrenia and other related psychotic disorders. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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