迟发性迟发性严重进行性角膜扁平化：角膜胶原交联9年后的并发症。

IF 1.9 3区医学 Q2 OPHTHALMOLOGY

Cornea Pub Date : 2025-03-03 DOI:10.1097/ICO.0000000000003839

Giulia Firmani, Christopher Ashton, Scott Hau, Romesh I Angunawela

{"title":"迟发性迟发性严重进行性角膜扁平化：角膜胶原交联9年后的并发症。","authors":"Giulia Firmani, Christopher Ashton, Scott Hau, Romesh I Angunawela","doi":"10.1097/ICO.0000000000003839","DOIUrl":null,"url":null,"abstract":"Purpose: We describe a case of late visual deterioration with marked progressive corneal flattening 9 years after crosslinking (CXL) was performed using the Dresden protocol.Case presentation: This patient with bilateral keratoconus underwent epithelium off crosslinking of the left eye only in 2007. After almost a decade of stability, he developed significant progressive corneal flattening with Descemet and stromal folds without inflammation, and a large hyperopic shift. Confocal microscopy showed keratocyte and sub-basal nerve plexus drop out. The fellow untreated eye was completely normal.Conclusions: Late-onset complications of CXL are rare, and this case represents an unusually delayed long-term complication. This rare anomaly does raise awareness of the long-term potential for complications after corneal CXL.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Delayed Late-Onset Severe Progressive Corneal Flattening: A Complication 9 Years After Corneal Collagen Crosslinking.\",\"authors\":\"Giulia Firmani, Christopher Ashton, Scott Hau, Romesh I Angunawela\",\"doi\":\"10.1097/ICO.0000000000003839\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Purpose: We describe a case of late visual deterioration with marked progressive corneal flattening 9 years after crosslinking (CXL) was performed using the Dresden protocol.Case presentation: This patient with bilateral keratoconus underwent epithelium off crosslinking of the left eye only in 2007. After almost a decade of stability, he developed significant progressive corneal flattening with Descemet and stromal folds without inflammation, and a large hyperopic shift. Confocal microscopy showed keratocyte and sub-basal nerve plexus drop out. The fellow untreated eye was completely normal.Conclusions: Late-onset complications of CXL are rare, and this case represents an unusually delayed long-term complication. This rare anomaly does raise awareness of the long-term potential for complications after corneal CXL.\",\"PeriodicalId\":10710,\"journal\":{\"name\":\"Cornea\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-03-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cornea\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/ICO.0000000000003839\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cornea","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/ICO.0000000000003839","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的：我们描述了一例晚期视力减退伴明显进行性角膜扁平化的病例，在使用德累斯顿方案进行交联（CXL） 9年后。病例介绍：本例双侧圆锥角膜患者仅于2007年接受左眼上皮脱交联手术。经过近十年的稳定后，他出现了明显的进行性角膜变平，伴有Descemet和间质褶皱，无炎症，并有很大的远视移位。共聚焦显微镜显示角质细胞和基底下神经丛脱落。另一只未经治疗的眼睛完全正常。结论：CXL的迟发性并发症是罕见的，本病例是一种罕见的迟发性长期并发症。这种罕见的异常确实提高了人们对角膜CXL术后长期潜在并发症的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Delayed Late-Onset Severe Progressive Corneal Flattening: A Complication 9 Years After Corneal Collagen Crosslinking.

Purpose: We describe a case of late visual deterioration with marked progressive corneal flattening 9 years after crosslinking (CXL) was performed using the Dresden protocol.

Case presentation: This patient with bilateral keratoconus underwent epithelium off crosslinking of the left eye only in 2007. After almost a decade of stability, he developed significant progressive corneal flattening with Descemet and stromal folds without inflammation, and a large hyperopic shift. Confocal microscopy showed keratocyte and sub-basal nerve plexus drop out. The fellow untreated eye was completely normal.

Conclusions: Late-onset complications of CXL are rare, and this case represents an unusually delayed long-term complication. This rare anomaly does raise awareness of the long-term potential for complications after corneal CXL.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cornea 医学-眼科学

CiteScore

5.20

自引率

10.70%

发文量

354

审稿时长

3-6 weeks

期刊介绍： For corneal specialists and for all general ophthalmologists with an interest in this exciting subspecialty, Cornea brings together the latest clinical and basic research on the cornea and the anterior segment of the eye. Each volume is peer-reviewed by Cornea''s board of world-renowned experts and fully indexed in archival format. Your subscription brings you the latest developments in your field and a growing library of valuable professional references. Sponsored by The Cornea Society which was founded as the Castroviejo Cornea Society in 1975.