植物细胞周期调节器控制病毒致病的核环境

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2025-03-04 DOI:10.1016/j.chom.2025.02.006

Xu Zhang, Ge Wang, Peng Zhang, Chunyan Chen, Jiucheng Zhang, Yumei Bian, Minmin Liu, Chenxu Niu, Fengze Sun, Yahui Wang, Genzhong Liu, Zhimin Wang, Fangfang Ma, Zhilong Bao

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引用次数: 0

摘要

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Plant cell-cycle regulators control the nuclear environment for viral pathogenesis

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Plant cell-cycle regulators control the nuclear environment for viral pathogenesis

The proper regulation of cell-cycle regulators is curial for both viral replication and host-plant adaptive growth during the viral pathogenesis. Mechanisms on reorchestrating RETINOBLASTOMA-RELATED 1 (RBR1), repressor of E2F transcription factor, and downstream genes in host-virus interactions are unclear. Here, we discover that anaphase-promoting complex/cyclosome (APC/C) E3 ligase activator cell division cycle 20 (CDC20) in tomato binds RBR1 or mediates cyclin D1 depletion to preserve RBR1-E2F complexes, while geminivirus or crinivirus repurposes APC/C^CDC20 activities to liberate E2Fs in two ways: activating APC/C^CDC20 to deplete RBR1 or blocking APC/C^CDC20 to stimulate cyclin-D1-mediated RBR1 depletion. The liberated E2Fs activate DNA polymerase or heat shock protein 70 gene transcription to favor virus propagation. The improper disruption of RBR1-E2F complexes via hijacking APC/C^CDC20 causes the host growth repression. We uncover a scenario in which the virus co-opts host APC/C^CDC20 to reprogram RBR1-E2F complex to favor its propagation while dampening host vitality.

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.