通往可靠和完整的药用植物基因组还有很长的路要走

IF 15.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Ling-Tong Cheng, Zi-Long Wang, Qian-Hao Zhu, Min Ye, Chu-Yu Ye
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引用次数: 0

摘要

长读DNA测序推动了药用植物基因组学的发展,到2025年2月,来自203种植物的400多个基因组测序完成。然而,许多基因组仍然存在组装和注释缺陷,只有11个端粒到端粒的无间隙组装。核心挑战仍然是确定与次生代谢物生物合成、调节和进化相关的基因。高质量的完整基因组是表征生物合成基因簇和实现强大的功能基因组学和合成生物学应用所必需的。我们建议在完善现有基因组组合的基础上,重点在不同品种中获得更多完整的基因组组合,借鉴作物基因组学研究的经验教训,并将基因组学前沿技术应用于药用植物基因组学研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A long road ahead to reliable and complete medicinal plant genomes

A long road ahead to reliable and complete medicinal plant genomes

Long-read DNA sequencing has propelled medicinal plant genomics forward, with over 400 genomes from 203 plants sequenced by February 2025. However, many genomes still have assembly and annotation flaws, with only 11 gapless telomere-to-telomere assemblies. The core challenge remains identifying genes linked to secondary metabolite biosynthesis, regulation and evolution. High-quality complete genomes are essential for characterizing biosynthetic gene clusters and for enabling robust functional genomics and synthetic biology applications. We propose to focus on achieving more complete genome assemblies in diverse varieties on the basis of refining the currently available ones, leverage lessons from crop genomics research, and apply the cutting-edge genomics technologies in research of medicinal plant genomics.

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来源期刊
Nature Communications
Nature Communications Biological Science Disciplines-
CiteScore
24.90
自引率
2.40%
发文量
6928
审稿时长
3.7 months
期刊介绍: Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.
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