基于发夹驱动的双茎环可编程变构策略的分子安全访问控制

IF 5.1 3区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Nanoscale Pub Date : 2025-03-04 DOI:10.1039/D4NR05369A
Yufeng Wang, Xiaokang Zhang, Peijun Shi, Wei Zhao, Bin Wang and Qiang Zhang
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引用次数: 0

摘要

DNA纳米技术的快速发展使得探索基于非计算复杂性的信息安全方法成为可能,为避免高性能计算方法对现代密码学的威胁提供了有效途径。然而,大多数分子信息安全方法既需要外界刺激,又需要特定的DNA信号,这对实验条件和DNA序列设计提出了很高的要求,限制了其实际应用和进一步发展。在此,我们提出了一种ehairpin驱动的双茎环可编程变构策略用于分子安全访问控制。具体来说,该策略通过响应特定的DNA输入信号,程序化地调节双茎环的构象变化,将分子构象变化转化为信号响应触发事件。我们通过EHairpin结构构建了可编程变构策略,实现了DNA信号驱动分子结构的时间响应,并进一步构建了多输入信号的分子开关响应电路。最后,我们实现了一个ehairpin驱动的分子安全门禁系统,该系统具有管理员认证、授权和用户认证三级安全保障机制。该策略为分子设备的安全访问控制提供了一种强有力的方法,进一步促进了下一代信息安全的发展,并为纳米机器的安全控制提供了一些新的思路,在生物传感和疾病诊断方面具有很大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

An EHairpin-driven double-stem-loop programmable allosteric strategy for molecular security access control†

An EHairpin-driven double-stem-loop programmable allosteric strategy for molecular security access control†

The rapid development of DNA nanotechnology has made it possible to explore information security methods based on non-computational complexity, providing an effective way to avoid the threats that high-performance computational methods pose to modern cryptography. However, most molecular information security methods require both external stimuli and specific DNA signals, placing high demands for experimental conditions and DNA-sequence design, limiting their practical application and further development. Herein, we proposed an EHairpin-driven double-stem-loop programmable allosteric strategy for molecular security access control. Specifically, this strategy regulates the conformational changes in the double-stem-loop programmatically by responding to specific DNA input signals, converting molecular conformational changes into signal-response triggering events. We constructed a programmable allosteric strategy through the EHairpin structure to achieve the temporal response of the DNA signal-driven molecular structure and further built a molecular-switch-response circuit for multiple input signals. Finally, we implemented an EHairpin-driven molecular security access control system, which has a three-level security assurance mechanism of administrator authentication, authorization, and user authentication. This strategy offers a powerful method for security access control of molecular devices, further promoting the development of next-generation information security and providing some new ideas for the secure control of nanomachines, which has great potential in biosensing and disease diagnosis.

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来源期刊
Nanoscale
Nanoscale CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
12.10
自引率
3.00%
发文量
1628
审稿时长
1.6 months
期刊介绍: Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers.Highly interdisciplinary, this journal appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics.
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