Yufeng Wang, Xiaokang Zhang, Peijun Shi, Wei Zhao, Bin Wang and Qiang Zhang
{"title":"基于发夹驱动的双茎环可编程变构策略的分子安全访问控制","authors":"Yufeng Wang, Xiaokang Zhang, Peijun Shi, Wei Zhao, Bin Wang and Qiang Zhang","doi":"10.1039/D4NR05369A","DOIUrl":null,"url":null,"abstract":"<p >The rapid development of DNA nanotechnology has made it possible to explore information security methods based on non-computational complexity, providing an effective way to avoid the threats that high-performance computational methods pose to modern cryptography. However, most molecular information security methods require both external stimuli and specific DNA signals, placing high demands for experimental conditions and DNA-sequence design, limiting their practical application and further development. Herein, we proposed an EHairpin-driven double-stem-loop programmable allosteric strategy for molecular security access control. Specifically, this strategy regulates the conformational changes in the double-stem-loop programmatically by responding to specific DNA input signals, converting molecular conformational changes into signal-response triggering events. We constructed a programmable allosteric strategy through the EHairpin structure to achieve the temporal response of the DNA signal-driven molecular structure and further built a molecular-switch-response circuit for multiple input signals. Finally, we implemented an EHairpin-driven molecular security access control system, which has a three-level security assurance mechanism of administrator authentication, authorization, and user authentication. This strategy offers a powerful method for security access control of molecular devices, further promoting the development of next-generation information security and providing some new ideas for the secure control of nanomachines, which has great potential in biosensing and disease diagnosis.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" 15","pages":" 9502-9514"},"PeriodicalIF":5.1000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An EHairpin-driven double-stem-loop programmable allosteric strategy for molecular security access control†\",\"authors\":\"Yufeng Wang, Xiaokang Zhang, Peijun Shi, Wei Zhao, Bin Wang and Qiang Zhang\",\"doi\":\"10.1039/D4NR05369A\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >The rapid development of DNA nanotechnology has made it possible to explore information security methods based on non-computational complexity, providing an effective way to avoid the threats that high-performance computational methods pose to modern cryptography. However, most molecular information security methods require both external stimuli and specific DNA signals, placing high demands for experimental conditions and DNA-sequence design, limiting their practical application and further development. Herein, we proposed an EHairpin-driven double-stem-loop programmable allosteric strategy for molecular security access control. Specifically, this strategy regulates the conformational changes in the double-stem-loop programmatically by responding to specific DNA input signals, converting molecular conformational changes into signal-response triggering events. We constructed a programmable allosteric strategy through the EHairpin structure to achieve the temporal response of the DNA signal-driven molecular structure and further built a molecular-switch-response circuit for multiple input signals. Finally, we implemented an EHairpin-driven molecular security access control system, which has a three-level security assurance mechanism of administrator authentication, authorization, and user authentication. This strategy offers a powerful method for security access control of molecular devices, further promoting the development of next-generation information security and providing some new ideas for the secure control of nanomachines, which has great potential in biosensing and disease diagnosis.</p>\",\"PeriodicalId\":92,\"journal\":{\"name\":\"Nanoscale\",\"volume\":\" 15\",\"pages\":\" 9502-9514\"},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2025-03-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanoscale\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/nr/d4nr05369a\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanoscale","FirstCategoryId":"88","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/nr/d4nr05369a","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
An EHairpin-driven double-stem-loop programmable allosteric strategy for molecular security access control†
The rapid development of DNA nanotechnology has made it possible to explore information security methods based on non-computational complexity, providing an effective way to avoid the threats that high-performance computational methods pose to modern cryptography. However, most molecular information security methods require both external stimuli and specific DNA signals, placing high demands for experimental conditions and DNA-sequence design, limiting their practical application and further development. Herein, we proposed an EHairpin-driven double-stem-loop programmable allosteric strategy for molecular security access control. Specifically, this strategy regulates the conformational changes in the double-stem-loop programmatically by responding to specific DNA input signals, converting molecular conformational changes into signal-response triggering events. We constructed a programmable allosteric strategy through the EHairpin structure to achieve the temporal response of the DNA signal-driven molecular structure and further built a molecular-switch-response circuit for multiple input signals. Finally, we implemented an EHairpin-driven molecular security access control system, which has a three-level security assurance mechanism of administrator authentication, authorization, and user authentication. This strategy offers a powerful method for security access control of molecular devices, further promoting the development of next-generation information security and providing some new ideas for the secure control of nanomachines, which has great potential in biosensing and disease diagnosis.
期刊介绍:
Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers.Highly interdisciplinary, this journal appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics.