Olga Bougie MD, MPH , Jessica N. Blom MD, PhD , Jonas Shellenberger MSc , Jessica Pudwell MSC, MPH , Susan B. Brogly PhD, MSc , Maria P. Velez MD, PhD
{"title":"子宫内膜异位症是缺血性和出血性中风的危险因素:一项基于人群的队列研究","authors":"Olga Bougie MD, MPH , Jessica N. Blom MD, PhD , Jonas Shellenberger MSc , Jessica Pudwell MSC, MPH , Susan B. Brogly PhD, MSc , Maria P. Velez MD, PhD","doi":"10.1016/j.jogc.2025.102798","DOIUrl":null,"url":null,"abstract":"<div><div>We completed a retrospective population-based cohort study using administrative data from Ontario female patients from 1993 to 2015 to examine the association between a diagnosis of endometriosis and stroke. We identified 166 853 female patients with a diagnosis of endometriosis and 333 706 unexposed female patients. Although the absolute risk of stroke was low, during the study period, 680 patients had ischemic stroke in the endometriosis group (28.2 cases per 100 000 person-years; 95% CI 26.1–30.4) and 1119 in the unexposed group (23.8 cases per 100 000 person-years; 95% CI 22.5–25.3)—adjusted hazard ratio 1.13 (95% CI 1.03–1.24). Confirmation of this association and consideration for clinical implications is warranted.</div></div>","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":"47 5","pages":"Article 102798"},"PeriodicalIF":2.0000,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Endometriosis as a Risk Factor for Ischemic and Hemorrhagic Stroke: A Population-Based Cohort Study\",\"authors\":\"Olga Bougie MD, MPH , Jessica N. Blom MD, PhD , Jonas Shellenberger MSc , Jessica Pudwell MSC, MPH , Susan B. Brogly PhD, MSc , Maria P. Velez MD, PhD\",\"doi\":\"10.1016/j.jogc.2025.102798\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>We completed a retrospective population-based cohort study using administrative data from Ontario female patients from 1993 to 2015 to examine the association between a diagnosis of endometriosis and stroke. We identified 166 853 female patients with a diagnosis of endometriosis and 333 706 unexposed female patients. Although the absolute risk of stroke was low, during the study period, 680 patients had ischemic stroke in the endometriosis group (28.2 cases per 100 000 person-years; 95% CI 26.1–30.4) and 1119 in the unexposed group (23.8 cases per 100 000 person-years; 95% CI 22.5–25.3)—adjusted hazard ratio 1.13 (95% CI 1.03–1.24). Confirmation of this association and consideration for clinical implications is warranted.</div></div>\",\"PeriodicalId\":16688,\"journal\":{\"name\":\"Journal of obstetrics and gynaecology Canada\",\"volume\":\"47 5\",\"pages\":\"Article 102798\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of obstetrics and gynaecology Canada\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1701216325000386\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of obstetrics and gynaecology Canada","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1701216325000386","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
我们利用1993-2015年安大略省女性的行政数据完成了一项基于人群的回顾性队列研究,以检查子宫内膜异位症诊断与中风之间的关系。我们确定了166 853名诊断为子宫内膜异位症的女性患者和333 706名未暴露的女性患者。虽然卒中的绝对风险很低,但在研究期间,子宫内膜异位症组有680例患者发生缺血性卒中(28.2例/ 10万人年,95% CI 26.1-30.4),未暴露组有1119例(23.8例/ 10万人年,95% CI 22.5-25.3) - aHR 1.13 (95% CI 1.03-1.24)。确认这种关联并考虑临床意义是有必要的。
Endometriosis as a Risk Factor for Ischemic and Hemorrhagic Stroke: A Population-Based Cohort Study
We completed a retrospective population-based cohort study using administrative data from Ontario female patients from 1993 to 2015 to examine the association between a diagnosis of endometriosis and stroke. We identified 166 853 female patients with a diagnosis of endometriosis and 333 706 unexposed female patients. Although the absolute risk of stroke was low, during the study period, 680 patients had ischemic stroke in the endometriosis group (28.2 cases per 100 000 person-years; 95% CI 26.1–30.4) and 1119 in the unexposed group (23.8 cases per 100 000 person-years; 95% CI 22.5–25.3)—adjusted hazard ratio 1.13 (95% CI 1.03–1.24). Confirmation of this association and consideration for clinical implications is warranted.
期刊介绍:
Journal of Obstetrics and Gynaecology Canada (JOGC) is Canada"s peer-reviewed journal of obstetrics, gynaecology, and women"s health. Each monthly issue contains original research articles, reviews, case reports, commentaries, and editorials on all aspects of reproductive health. JOGC is the original publication source of evidence-based clinical guidelines, committee opinions, and policy statements that derive from standing or ad hoc committees of the Society of Obstetricians and Gynaecologists of Canada. JOGC is included in the National Library of Medicine"s MEDLINE database, and abstracts from JOGC are accessible on PubMed.