{"title":"子宫内膜容受性分析的临床疗效及影响着床窗移位的因素研究。","authors":"Shaoyuan Xu, Honglu Diao, Yao Xiong, Changjun Zhang, Ying Zhang, Yuanzhen Zhang","doi":"10.1038/s41598-025-91745-y","DOIUrl":null,"url":null,"abstract":"<p><p>The endometrial receptive status is critical for a successful embryo implantation, but it only last for a short period of time, and the window of implantation (WOI) of each woman changes individually, which will lead to poor outcomes of assisted reproduction. This so-called WOI can be detected by molecular diagnostic method, endometrial receptivity analysis (ERA), which was gradually applied to clinical practice. This study aimed to evaluate the clinical efficacy of personalized embryo transfer (pET) guided by ERA in patients with and without RIF. A total of 3605 patients with previous failed embryo transfer (ET) cycle in the reproductive medicine center of Renmin Hospital Hubei University of Medicine from January 2016 to October 2022 were retrospectively analyzed. The 3605 patients were divided into non-RIF group and RIF group, among which 782 patients who received ERA test underwent personalized embryo transfer (pET). The decision whether to accept ERA test or not was based on the patient's voluntary choice. We divided the 782 patients into normal WOI group and displaced WOI group according to the result of ERA test. The pregnancy outcomes were compared between the different groups. The age, number of previous ET cycle and serum E2/P ratio were mainly analyzed to investigate its relationship with displaced WOI. The clinical pregnancy rate and live birth rate in non-RIF with pET group were higher than that of non-RIF with non-personalized embryo transfer (npET) group (64.5% vs 58.3%, P = 0.025; 57.1% vs 48.3%, P = 0.003). The clinical pregnancy rate and the live birth rate in RIF with pET group were significantly higher than that of RIF with npET group (62.7% vs 49.3%, P < 0.001; 52.5% vs 40.4%, P < 0.001) after propensity score matching (PSM). The early abortion rate in the non-RIF with pET group was lower than that in the non-RIF with npET group (8.2% vs 13.0%, P = 0.038). There was a significant difference in age and the number of previous failed ET cycle between the normal WOI group and displaced WOI group (age: 32.26 vs 33.53 years, P < 0.001; the number of previous failed ET cycle: 1.68 vs 2.04, P < 0.001). Logistic regression analysis also showed that the age and number of previous failed ET cycles were positively correlated with displaced WOI. The displaced WOI rate increased gradually with the increase of age and number of previous failed ET cycle; the displaced WOI rate in the median group (4.46 < E2/P ≤ 10.39 pg/ng) was significantly lower than that in the other two groups (54.8% vs 40.6% vs 58.5%, P < 0.001). The clinical pregnancy rate and live birth rate of patients with previous failed ET cycle was improved after pET guided by ERA, especially in RIF patients; the early abortion rate of the non-RIF patient was reduced after pET guided by ERA. An appropriate E2/P ratio was beneficial for maintaining endometrial receptivity state, and the age and number of previous failed ET cycle was correlated with increased displaced WOI.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7326"},"PeriodicalIF":3.9000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873133/pdf/","citationCount":"0","resultStr":"{\"title\":\"The study on the clinical efficacy of endometrial receptivity analysis and influence factors of displaced window of implantation.\",\"authors\":\"Shaoyuan Xu, Honglu Diao, Yao Xiong, Changjun Zhang, Ying Zhang, Yuanzhen Zhang\",\"doi\":\"10.1038/s41598-025-91745-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The endometrial receptive status is critical for a successful embryo implantation, but it only last for a short period of time, and the window of implantation (WOI) of each woman changes individually, which will lead to poor outcomes of assisted reproduction. This so-called WOI can be detected by molecular diagnostic method, endometrial receptivity analysis (ERA), which was gradually applied to clinical practice. This study aimed to evaluate the clinical efficacy of personalized embryo transfer (pET) guided by ERA in patients with and without RIF. A total of 3605 patients with previous failed embryo transfer (ET) cycle in the reproductive medicine center of Renmin Hospital Hubei University of Medicine from January 2016 to October 2022 were retrospectively analyzed. The 3605 patients were divided into non-RIF group and RIF group, among which 782 patients who received ERA test underwent personalized embryo transfer (pET). The decision whether to accept ERA test or not was based on the patient's voluntary choice. We divided the 782 patients into normal WOI group and displaced WOI group according to the result of ERA test. The pregnancy outcomes were compared between the different groups. The age, number of previous ET cycle and serum E2/P ratio were mainly analyzed to investigate its relationship with displaced WOI. The clinical pregnancy rate and live birth rate in non-RIF with pET group were higher than that of non-RIF with non-personalized embryo transfer (npET) group (64.5% vs 58.3%, P = 0.025; 57.1% vs 48.3%, P = 0.003). The clinical pregnancy rate and the live birth rate in RIF with pET group were significantly higher than that of RIF with npET group (62.7% vs 49.3%, P < 0.001; 52.5% vs 40.4%, P < 0.001) after propensity score matching (PSM). The early abortion rate in the non-RIF with pET group was lower than that in the non-RIF with npET group (8.2% vs 13.0%, P = 0.038). There was a significant difference in age and the number of previous failed ET cycle between the normal WOI group and displaced WOI group (age: 32.26 vs 33.53 years, P < 0.001; the number of previous failed ET cycle: 1.68 vs 2.04, P < 0.001). Logistic regression analysis also showed that the age and number of previous failed ET cycles were positively correlated with displaced WOI. The displaced WOI rate increased gradually with the increase of age and number of previous failed ET cycle; the displaced WOI rate in the median group (4.46 < E2/P ≤ 10.39 pg/ng) was significantly lower than that in the other two groups (54.8% vs 40.6% vs 58.5%, P < 0.001). The clinical pregnancy rate and live birth rate of patients with previous failed ET cycle was improved after pET guided by ERA, especially in RIF patients; the early abortion rate of the non-RIF patient was reduced after pET guided by ERA. An appropriate E2/P ratio was beneficial for maintaining endometrial receptivity state, and the age and number of previous failed ET cycle was correlated with increased displaced WOI.</p>\",\"PeriodicalId\":21811,\"journal\":{\"name\":\"Scientific Reports\",\"volume\":\"15 1\",\"pages\":\"7326\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873133/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scientific Reports\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1038/s41598-025-91745-y\",\"RegionNum\":2,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scientific Reports","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1038/s41598-025-91745-y","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
子宫内膜接受状态是胚胎着床成功的关键,但其持续时间较短,且每个女性的着床窗口期(window of着床,WOI)各不相同,会导致辅助生殖的效果较差。这种所谓的WOI可以通过分子诊断方法子宫内膜容受性分析(ERA)来检测,并逐渐应用于临床。本研究旨在评价ERA引导下的个体化胚胎移植(pET)在有和无RIF患者中的临床疗效。回顾性分析2016年1月至2022年10月湖北医科大学人民医院生殖医学中心既往胚胎移植(ET)周期失败患者3605例。3605例患者分为非RIF组和RIF组,其中782例接受ERA检测的患者进行了个性化胚胎移植(pET)。是否接受ERA检测是基于患者的自愿选择。根据ERA检测结果将782例患者分为正常WOI组和移位WOI组。比较两组妊娠结局。主要分析年龄、既往ET周期数、血清E2/P比值与WOI移位的关系。非rif合并pET组临床妊娠率和活产率高于非rif合并非个体化胚胎移植(npET)组(64.5% vs 58.3%, P = 0.025;57.1% vs 48.3%, P = 0.003)。RIF合并pET组临床妊娠率和活产率均显著高于RIF合并npET组(62.7% vs 49.3%, P
The study on the clinical efficacy of endometrial receptivity analysis and influence factors of displaced window of implantation.
The endometrial receptive status is critical for a successful embryo implantation, but it only last for a short period of time, and the window of implantation (WOI) of each woman changes individually, which will lead to poor outcomes of assisted reproduction. This so-called WOI can be detected by molecular diagnostic method, endometrial receptivity analysis (ERA), which was gradually applied to clinical practice. This study aimed to evaluate the clinical efficacy of personalized embryo transfer (pET) guided by ERA in patients with and without RIF. A total of 3605 patients with previous failed embryo transfer (ET) cycle in the reproductive medicine center of Renmin Hospital Hubei University of Medicine from January 2016 to October 2022 were retrospectively analyzed. The 3605 patients were divided into non-RIF group and RIF group, among which 782 patients who received ERA test underwent personalized embryo transfer (pET). The decision whether to accept ERA test or not was based on the patient's voluntary choice. We divided the 782 patients into normal WOI group and displaced WOI group according to the result of ERA test. The pregnancy outcomes were compared between the different groups. The age, number of previous ET cycle and serum E2/P ratio were mainly analyzed to investigate its relationship with displaced WOI. The clinical pregnancy rate and live birth rate in non-RIF with pET group were higher than that of non-RIF with non-personalized embryo transfer (npET) group (64.5% vs 58.3%, P = 0.025; 57.1% vs 48.3%, P = 0.003). The clinical pregnancy rate and the live birth rate in RIF with pET group were significantly higher than that of RIF with npET group (62.7% vs 49.3%, P < 0.001; 52.5% vs 40.4%, P < 0.001) after propensity score matching (PSM). The early abortion rate in the non-RIF with pET group was lower than that in the non-RIF with npET group (8.2% vs 13.0%, P = 0.038). There was a significant difference in age and the number of previous failed ET cycle between the normal WOI group and displaced WOI group (age: 32.26 vs 33.53 years, P < 0.001; the number of previous failed ET cycle: 1.68 vs 2.04, P < 0.001). Logistic regression analysis also showed that the age and number of previous failed ET cycles were positively correlated with displaced WOI. The displaced WOI rate increased gradually with the increase of age and number of previous failed ET cycle; the displaced WOI rate in the median group (4.46 < E2/P ≤ 10.39 pg/ng) was significantly lower than that in the other two groups (54.8% vs 40.6% vs 58.5%, P < 0.001). The clinical pregnancy rate and live birth rate of patients with previous failed ET cycle was improved after pET guided by ERA, especially in RIF patients; the early abortion rate of the non-RIF patient was reduced after pET guided by ERA. An appropriate E2/P ratio was beneficial for maintaining endometrial receptivity state, and the age and number of previous failed ET cycle was correlated with increased displaced WOI.
期刊介绍:
We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections.
Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021).
•Engineering
Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live.
•Physical sciences
Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics.
•Earth and environmental sciences
Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems.
•Biological sciences
Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants.
•Health sciences
The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.