Guilherme Dionir Back, Murilo Rezende Oliveira, Guilherme Peixoto Tinoco Arêas, Patricia Faria Camargo, Cássia da Luz Goulart, Claudio Ricardo de Oliveira, José Carlos Bonjorno Junior, Flávia Rossi Caruso Bonjourno, Ross Arena, Audrey Borghi-Silva
{"title":"The impact of COVID-19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness?","authors":"Guilherme Dionir Back, Murilo Rezende Oliveira, Guilherme Peixoto Tinoco Arêas, Patricia Faria Camargo, Cássia da Luz Goulart, Claudio Ricardo de Oliveira, José Carlos Bonjorno Junior, Flávia Rossi Caruso Bonjourno, Ross Arena, Audrey Borghi-Silva","doi":"10.14814/phy2.70216","DOIUrl":null,"url":null,"abstract":"<p><p>The impact of COVID-19 on cardiorespiratory fitness (CRF) is negative, increasing the likelihood of exertional symptoms such as fatigue and shortness of breath, and adversely affecting vascular function, impairing cardiovascular health. This study investigated endothelial function and its relationship with CRF in patients who have recovered COVID-19. Patients were evaluated 1 month after infection, including clinical assessment, pulmonary function, endothelial function (measured by flow-mediated dilation), and cardiopulmonary exercise testing. COVID-19 survivors exhibited reduced exercise capacity, with poor values of peak V̇O<sub>2peak</sub> and FMD (%) according to disease severity. However, endothelial function was worse in COVID-19 patients, regardless of severity, compared to the control group. Significant associations were observed between poorer FMD (%) and peak V̇O<sub>2</sub>, workload, circulatory power, and V̇O<sub>2peak</sub>/WR. Endothelial function was significantly associated with CRF in COVID-19 patients according to disease severity. Strategies to improve CRF and reduce the negative impacts of endothelial function damage should be further investigated.</p>","PeriodicalId":20083,"journal":{"name":"Physiological Reports","volume":"13 5","pages":"e70216"},"PeriodicalIF":2.2000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872806/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physiological Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14814/phy2.70216","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
The impact of COVID-19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness?
The impact of COVID-19 on cardiorespiratory fitness (CRF) is negative, increasing the likelihood of exertional symptoms such as fatigue and shortness of breath, and adversely affecting vascular function, impairing cardiovascular health. This study investigated endothelial function and its relationship with CRF in patients who have recovered COVID-19. Patients were evaluated 1 month after infection, including clinical assessment, pulmonary function, endothelial function (measured by flow-mediated dilation), and cardiopulmonary exercise testing. COVID-19 survivors exhibited reduced exercise capacity, with poor values of peak V̇O2peak and FMD (%) according to disease severity. However, endothelial function was worse in COVID-19 patients, regardless of severity, compared to the control group. Significant associations were observed between poorer FMD (%) and peak V̇O2, workload, circulatory power, and V̇O2peak/WR. Endothelial function was significantly associated with CRF in COVID-19 patients according to disease severity. Strategies to improve CRF and reduce the negative impacts of endothelial function damage should be further investigated.
期刊介绍：
Physiological Reports is an online only, open access journal that will publish peer reviewed research across all areas of basic, translational, and clinical physiology and allied disciplines. Physiological Reports is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.
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