(Cornea Bank Debrecen已有30年历史)。

IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
László Módis, Miklós Ágoston Lukács, Sára Makhoul, Mariann Fodor
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引用次数: 0

摘要

目的:介绍Debrecen眼库运营30年(1994-2023),角膜供体的人口统计学特征,供体组织的采购、储存、利用和分配情况,揭示眼库运营的长期效果。方法:回顾性分析德国德布勒森大学眼科1994年至2023年间的眼库实践。我们收集了角膜捐赠(捐赠者的性别和年龄、死亡原因、从死亡到摘除、保存和最终移植供体组织的时间)、保存的角膜(内皮细胞密度)和手术(干预类型、适应证)的数据。我们的器官库收集来自尸体、多器官和活体捐赠者的组织。供体在低温条件下最多保存14天。我们的工作还包括羊膜的保存、深度冷冻和使用,以及阔筋膜的储存和使用。结果:角膜银行Debrecen于1994年至2023年间进行了3270例角膜保存。根据保存角膜的数据,57.8%的角膜巩膜盘来自尸体,37.6%来自多器官,4.6%来自活体供体。献血者平均年龄为55.5±11.8岁。供体角膜内皮细胞平均密度为2235.6±158个/mm2。病理研究所报告死亡至去核平均时间为12.3±5.2小时,死亡至保存平均时间为14.9±6.3小时。供体组织保存后(+4.0°C Eusol-C, Alchimia, Italy),平均使用时间为6.1±2.3天。在保存的角膜中,20.3%被丢弃,最常见的原因是血清学阳性(25.6%的非移植供体角膜中有乙型和丙型肝炎)。根据眼库数据,1994年至2023年间共进行了2864例角膜移植手术。最常见的手术指征是大疱性角膜病变(21.6%)。2011 - 2023年板层手术率为6.4%。2006年至2023年共施行羊膜移植312例。结论:Cornea Bank Debrecen自成立以来一直在不断发展,符合法律要求和欧洲专业标准。从尸体、多器官和活体供体中获取供体也是可行的。除了角膜,羊膜和阔筋膜组织也可在我们的银行,为各种眼科病理的手术治疗提供了背景。Orv Hetil. 2025;166(9): 341 - 350。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The Cornea Bank Debrecen is thirty years old].

Objective: To present the 30 years of operation of the Eye Bank Debrecen (1994–2023), the demographic characteristics of corneal donors, the procurement, storage, utilization, and distribution of donor tissues, moreover, to disclose the long-term results of eye bank practice. Methods: We performed a retrospective analysis of eye bank practices between 1994 and 2023 at the Department of Ophthalmology, University of Debrecen. We collected data on corneal donation (gender and age of donor, cause of death, time from death to removal, preservation, and finally transplantation of donor tissue), preserved corneas (endothelial cell density), and operations (type of intervention, indication). Our bank collects tissue from cadavers, multiorgan, and living donors. Donors are stored in hypothermic conditions for a maximum of 14 days. Our activities also include the preservation, deep freezing and use of amniotic membrane, as well as the storage and use of fascia lata. Results: The Cornea Bank Debrecen performed 3270 corneal preservations between 1994 and 2023. Based on the data of the preserved corneas, 57.8% of the corneoscleral discs derived from cadaver, 37.6% from multiorgan and 4.6% from living donor. The mean age of donors was 55.5 ± 11.8 years. The average endothelial cell density of donor corneas was 2235.6 ± 158/mm2. The mean time between death and enucleation from the pathology institute was 12.3 ± 5.2 hours and the mean time between death and preservation was 14.9 ± 6.3 hours. After preservation (+4.0 °C Eusol-C, Alchimia, Italy), donor tissue was used at an average of 6.1 ± 2.3 days. Of the preserved corneas, 20.3% were discarded, the most common reason being serological positivity (hepatitis B and C in 25.6% of non-transplanted donor corneas). Based on the eye bank data, a total of 2864 corneal transplantations were performed between 1994 and 2023. The most common surgical indication was bullous keratopathy (21.6%). The rate of lamellar surgical techniques was 6.4% from 2011 to 2023. From 2006 to 2023, 312 amniotic membrane transplantations were performed. Conclusion: The Cornea Bank Debrecen has been continuously developing since its foundation, complying with the legal requirements and European professional standards. Donor harvesting from cadaver, multiorgan and living donors is also feasible. In addition to corneas, amniotic membrane and fascia lata tissue are also available in our bank, providing a background for the surgical treatment of various ophthalmological pathologies. Orv Hetil. 2025; 166(9): 341–350.

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来源期刊
Orvosi hetilap
Orvosi hetilap MEDICINE, GENERAL & INTERNAL-
CiteScore
1.20
自引率
50.00%
发文量
274
期刊介绍: The journal publishes original and review papers in the fields of experimental and clinical medicine. It covers epidemiology, diagnostics, therapy and the prevention of human diseases as well as papers of medical history. Orvosi Hetilap is the oldest, still in-print, Hungarian publication and also the one-and-only weekly published scientific journal in Hungary. The strategy of the journal is based on the Curatorium of the Lajos Markusovszky Foundation and on the National and International Editorial Board. The 150 year-old journal is part of the Hungarian Cultural Heritage.
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