遗传老年科学与阿尔茨海默病：多效性是关键！

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-03-03 DOI:10.1177/13872877251321182

Michelle Shardell, Chixiang Chen

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引用次数: 0

摘要

老年科学旨在了解衰老的生物学如何成为多种与年龄相关的健康状况的共同因素。影响多种性状的遗传变异被称为多效性效应。Pan及其同事的研究应用现代统计模型，通过评估遗传变异与阿尔茨海默病、相关痴呆和其他与年龄相关的合并症（如冠心病、高脂血症、癌症）的联合关系，来识别具有潜在多效性的遗传变异。在潘及其同事的推动下，这篇评论介绍了遗传老科学的概念，作为识别对多种年龄相关健康状况具有潜在多向性影响的遗传变异的范例。

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Genetic geroscience and Alzheimer's disease: The pleiotropy is the point!

Geroscience aims to understand how the biology of aging serves as a shared contributor to multiple age-related health conditions. Genetic variants that influence multiple traits are said to exert pleiotropic effects. The study by Pan and colleagues applied a modern statistical model to identify genetic variants with potentially pleiotropic effects by assessing their joint association with Alzheimer's disease and related dementias and another age-related comorbidity (e.g., coronary heart disease, hyperlipidemia, cancer). Motivated by Pan and colleagues, this commentary introduces the concept of genetic geroscience as a paradigm for identifying genetic variants with potentially pleotropic effects on multiple age-related health conditions.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.