股骨近端骨折的甲状腺功能正常综合征(ESS):老年患者术后结果的概念验证评估。

IF 3.3 4区 医学 Q1 Medicine
E Pesare, G Maccagnano, G Vicenti, I Caruso, L Di Gioia, M Coviello, W Ginestra, M D'Aprile, C Gallo, F Giorgino, B Moretti
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引用次数: 0

摘要

目的:甲状腺功能不全综合征(ESS)在几种疾病中的诊断与不良预后相关,股骨近端骨折是老年患者中最常见的损伤之一,是导致残疾和死亡的主要原因。目前尚无研究评估股骨近端骨折合并ESS患者的死亡率。本研究的目的是评估受ESS影响的老年股骨近端骨折患者的潜在更高死亡率。材料和方法:在这项概念验证性研究中,所有年龄大于65岁且诊断为股骨近端骨折的患者均被纳入研究。他们都接受了手术治疗。主要的排除标准是急性心肺事件、肿瘤疾病和任何甲状腺或内分泌病理。结果:36例符合标准的患者入组:其中20例诊断为ESS (a组),16例甲状腺功能正常(B组)。分别于术后1个月、3个月、6个月和12个月评估死亡率。入组患者的生存分析显示,无论基线合并症如何,ESS患者的死亡率更高(p = 0.049)。结论:ESS可作为老年股骨近端骨折患者全因死亡率的预测因素之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Euthyroid Sick Syndrome (ESS) in proximal femoral fractures: a proof-of-concept evaluation of postoperative outcomes in elderly patients.

Objective: The diagnosis of euthyroid sick syndrome (ESS) in several diseases has been associated with poor outcomes, and proximal femur fractures are among the most common injuries in elderly patients, representing a leading cause of disability and mortality. There are no studies evaluating the mortality rate in patients with proximal femur fractures and ESS. The aim of our study was to evaluate a potential higher mortality rate in geriatric patients with proximal femur fracture and affected by ESS.

Materials and methods: In this proof-of-concept study, all patients older than 65 years with a diagnosis of proximal femur fracture were included. They were all treated surgically. The main exclusion criteria were acute cardio-pulmonary events, neoplastic diseases, and any thyroid or endocrine pathology.

Results: Thirty-six patients who met our criteria were enrolled: 20 of them had a diagnosis of ESS (Group A), while 16 had a normal thyroid function as control (Group B). The mortality rate was evaluated at one month, three months, six, and twelve months after surgery. The survival analysis of enrolled patients showed a higher mortality rate in patients with ESS (p = 0.049) regardless of baseline comorbidities.

Conclusions: The ESS could be included among the predictive factors of all-cause mortality in geriatric patients with proximal femur fracture.

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来源期刊
CiteScore
5.30
自引率
6.10%
发文量
906
审稿时长
2-4 weeks
期刊介绍: European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)
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