酒精损害学习和条件眨眼反应的时间。

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-02-28 DOI:10.1016/j.brainres.2025.149545

Fredrik Johansson , Vincent Rydberg , Nils-Erik Arn , Johannes Lundin , Artem Gornov , Robert Winton , Guy Madison , Germund Hesslow , Anders Rasmussen

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引用次数: 0

摘要

酒精会损害运动能力，但目前还不清楚为什么会这样。在这里，我们研究了酒精中毒对条件反射眨眼反应的影响，这是一种依赖小脑的经典条件反射形式。在实验1中，将18名学生在饮酒1‰前后的条件反应与26名非饮酒对照的表现进行了比较。在实验2中，17名学生被反复测试血液酒精浓度，最高可达1‰。结果显示，饮酒后条件反射的百分比和时间逐渐下降，血液酒精含量超过0.5‰时出现明显的损伤。这些发现与先前的观点一致，即与酒精摄入有关的运动缺陷与对小脑的影响有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Alcohol impairs learning and timing of conditioned eyeblink responses

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Alcohol impairs learning and timing of conditioned eyeblink responses

Alcohol impairs motor performance, but it remains unclear precisely why this is the case. Here, we examine the effects of alcohol intoxication on conditioned eyeblink responses, a form of classical conditioning dependent on the cerebellum. In experiment 1, the conditioned responses of 18 students before and after alcohol consumption up to 1 ‰ were compared against the performance of 26 non-drinking controls. In experiment 2, 17 students were tested repeatedly at increasing blood alcohol levels up to 1 ‰. The results reveal a gradual decrease in both the percentage and timing of conditioned responses following alcohol consumption, with pronounced impairments emerging at blood alcohol content levels exceeding 0.5 ‰. These findings are consistent with the idea that the motor deficits associated with alcohol consumption are linked to effects on the cerebellum.

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.