畜牧业血液废物转化为生物塑料：血浆蛋白淀粉样原纤维。

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-04-14 DOI:10.1021/acs.biomac.4c01564

Shuang Ding , Xing Chen , Yixiang Wang , Nana Zhang , Yuan Tao , Huayu Yang , Bowen Yan , Daming Fan

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引用次数: 0

摘要

本研究提出了一种利用家畜血浆蛋白未充分利用的资源来生产基于淀粉样原纤维的生物塑料薄膜的新方法。经酸性加热，20 h的孵育得到成熟的半柔性原纤维，平均长度为0.65 μm，持久长度为261 nm。利用Thioflavin T强度、圆二色性和FTIR光谱对其进行了表征，发现其具有氢键稳定的交叉β片结构。血浆蛋白淀粉样蛋白原纤维与聚乙烯醇（PVA）或甲基纤维素（MC）的整合产生的生物塑料薄膜具有光滑和均匀的微形态，增强的韧性和水稳定性，PVA基薄膜具有优异的延伸率~ 300%，适用于食品包装应用。与石油基塑料相比，血浆淀粉样蛋白纤维薄膜表现出优越的可持续性足迹（约92%）。这项工作强调了血浆蛋白淀粉样原纤维在生物塑料应用中的潜力，与生态友好型废物管理和循环经济的全球需求相一致。

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Upcycling of Livestock Industry Blood Waste into Bioplastics: Plasma Protein-Based Amyloid Fibrils

This study presents a novel approach to harnessing the underutilized resource of livestock blood plasma proteins to produce bioplastic films based on amyloid fibrils. Upon acidic heating, a 20-h incubation period resulted in mature, semiflexible fibrils with an average length of 0.65 μm and a persistence length of 261 nm. Characterization using Thioflavin T intensity, circular dichroism, and FTIR spectroscopy revealed a cross-β-sheet structure stabilized by hydrogen bonding. The integration of plasma protein amyloid fibrils with poly(vinyl alcohol) (PVA) or methyl cellulose (MC) yielded bioplastic films that exhibit smooth and homogeneous micromorphology, enhanced toughness, and water stability, with PVA-based films demonstrating an exceptional elongation of ∼300%, suitable for food packaging applications. Compared to petroleum-based plastics, plasma amyloid fibril-incorporated films demonstrated a superior sustainability footprint (∼92%). This work underscores the potential of plasma protein amyloid fibrils in bioplastic applications, aligning with the global imperative for eco-friendly waste management and a circular economy.

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.