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IF 9.4 1区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Cachexia Sarcopenia and Muscle Pub Date : 2025-03-04 DOI:10.1002/jcsm.13757

Tae Seop Lim, Sujin Kwon, Sung A. Bae, Hye Yeon Chon, Seol A. Jang, Ja Kyung Kim, Chul Sik Kim, Seok Won Park, Kyoung Min Kim

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引用次数: 0

摘要

背景本研究旨在利用英国生物库队列的数据，调查代谢功能障碍相关性脂肪性肝病（MASLD）患者的手握力（HGS）与心血管疾病（CVD）之间的关系。方法本研究共招募了 201 563 名参与者。使用 Jamar J00105 液压手动测力计测量 HGS。MASLD的定义是肝脏脂肪变性并伴有一个或多个心脏代谢标准。肝脂肪变性用脂肪肝指数≥60来确定。肝纤维化晚期的定义是肝纤维化-4（FIB-4）评分> 2.67。为研究心血管疾病发病率的差异，将男性和女性参与者分为非 MASLD 组、MASLD 高 HGS 组、MASLD 中 HGS 组和 MASLD 低 HGS 组。结果在研究参与者中，75 498 人（37.5%）被确诊为 MASLD，平均年龄为 56.5 岁，40.6% 为男性。中位随访时间为 13.1 年。不同组别的心血管疾病事件发生率显著增加：非 MASLD 男性为 10.9%，MASLD 高 HGS 男性为 13.3%，MASLD 中 HGS 男性为 14.8%，MASLD 低 HGS 男性为 18.4%（p <0.001）。在女性中，非 MASLD 患者发生心血管疾病事件的频率为 6.1%，MASLD 高 HGS 患者为 9.2%，MASLD 中 HGS 患者为 10.7%，MASLD 低 HGS 患者为 13.3%（p <0.001）。以非MASLD组为参照，MASLD患者发生心血管疾病的多变量调整危险比（HRs）（95%置信区间[CI]）因HGS而异。在男性 MASLD 患者中，高 HGS 的 HRs（95% 置信区间）为 1.03（0.96-1.10），中 HGS 为 1.14（1.07-1.21），低 HGS 为 1.38（1.30-1.46）；在女性 MASLD 患者中，高 HGS 为 1.07（0.97-1.18），中 HGS 为 1.25（1.14-1.37），低 HGS 为 1.56（1.43-1.72）。在 MASLD 患者中，无论是否存在晚期肝纤维化，随着 HGS 的降低，心血管疾病事件的发生率都会增加（所有 p 均为 0.001）。结论这项利用英国生物库进行的大型前瞻性队列研究表明，在 MASLD 患者中，HGS 的降低与心血管疾病风险的增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Association Between Handgrip Strength and Cardiovascular Disease Risk in MASLD: A Prospective Study From UK Biobank

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Association Between Handgrip Strength and Cardiovascular Disease Risk in MASLD: A Prospective Study From UK Biobank

Background

This study aimed to investigate the association between handgrip strength (HGS) and cardiovascular disease (CVD) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) using data from the UK Biobank cohort.

Methods

A total of 201 563 participants were enrolled in this study. The HGS was measured using a Jamar J00105 hydraulic hand dynamometer. MASLD was defined as the presence of hepatic steatosis accompanied by one or more cardiometabolic criteria. Hepatic steatosis was identified using a fatty liver index ≥ 60. Advanced liver fibrosis was defined by a fibrosis-4 (FIB-4) score > 2.67. To examine the differences in the incidence of CVD, male and female participants were divided into non-MASLD, MASLD with high HGS, MASLD with middle HGS, and MASLD with low-HGS groups.

Results

Of the study participants, 75 498 (37.5%) were diagnosed with MASLD, with a mean age of 56.5 years, and 40.6% were male. The median follow-up duration was 13.1 years. The frequency of incident CVD events increased significantly across groups: 10.9% in non-MASLD, 13.3% in MASLD with high HGS, 14.8% in MASLD with middle HGS, and 18.4% in MASLD with low HGS for males (p < 0.001). In females, the frequency of incident CVD events was 6.1% in non-MASLD, 9.2% in MASLD with high HGS, 10.7% in MASLD with middle HGS, and 13.3% in MASLD with low HGS (p < 0.001). Using the non-MASLD group as a reference, multivariate-adjusted hazard ratios (HRs) (95% confidence intervals [CI]) for CVD varied according to HGS in individuals with MASLD. In males with MASLD, HRs (95% CI) were 1.03 (0.96–1.10) for high HGS, 1.14 (1.07–1.21) for middle HGS, and 1.38 (1.30–1.46) for low HGS; in females with MASLD, they were 1.07 (0.97–1.18) for high HGS, 1.25 (1.14–1.37) for middle HGS, and 1.56 (1.43–1.72) for low HGS. The incidence of CVD events increased as HGS decreased in participants with MASLD, regardless of the presence or absence of advanced liver fibrosis (all p < 0.001).

Conclusions

This large prospective cohort study using the UK Biobank showed that in MASLD, a decrease in HGS was associated with increased CVD risk.

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来源期刊

Journal of Cachexia Sarcopenia and Muscle MEDICINE, GENERAL & INTERNAL-

CiteScore

13.30

自引率

12.40%

发文量

234

审稿时长

16 weeks

期刊介绍： The Journal of Cachexia, Sarcopenia and Muscle is a peer-reviewed international journal dedicated to publishing materials related to cachexia and sarcopenia, as well as body composition and its physiological and pathophysiological changes across the lifespan and in response to various illnesses from all fields of life sciences. The journal aims to provide a reliable resource for professionals interested in related research or involved in the clinical care of affected patients, such as those suffering from AIDS, cancer, chronic heart failure, chronic lung disease, liver cirrhosis, chronic kidney failure, rheumatoid arthritis, or sepsis.