Ying Cao, Xuguang Li, Jing Gao, Nan Zhang, Guoqian Zhang, Shen Li
{"title":"揭示白细胞计数差异与抑郁之间的因果关系：一项双向双样本孟德尔随机研究","authors":"Ying Cao, Xuguang Li, Jing Gao, Nan Zhang, Guoqian Zhang, Shen Li","doi":"10.1155/da/3131579","DOIUrl":null,"url":null,"abstract":"<div>\n <p><b>Background:</b> The link between white blood cells (WBC) and depression has been studied, but the causal relationship remains unclear. This study aimed to elucidate the potential bidirectional causal links between six specific WBC count features and depression using a two-sample Mendelian randomization (MR) analysis, leveraging summary statistics from genome-wide association studies (GWAS).</p>\n <p><b>Method:</b> The dataset on depression (<i>N</i> = 406,986) was sourced from the FinnGen database, while the dataset on WBC (<i>N</i> = 563,085) was obtained from a combined dataset of Blood Cell Consortium (BCX) and UK Biobank. The MR analyses employed include inverse variance weighted (IVW), MR-Egger, weighted median, contamination mixture method (conmix), and constrained maximum likelihood-based Mendelian randomization (cML-MA). A threshold <i>p</i> < 0.05 after false discovery rate (FDR) correction was set as the criterion for causality based on IVW.</p>\n <p><b>Results:</b> Reverse MR analysis indicated a causal relationship where depression leads to an increase in overall WBC count (IVW beta = 0.031, <i>p</i> = 0.015, <i>p</i><sub>FDR</sub> = 0.044) and specifically in basophil count (IVW beta = 0.038, <i>p</i> = 0.006, <i>p</i><sub>FDR</sub> = 0.038), with a marginally significant impact on lymphocyte count (beta = 0.029, <i>p</i> = 0.036, <i>p</i><sub>FDR</sub> = 0.071). Furthermore, forward MR analysis suggested a potential role of monocyte count in decreasing depression risk (<i>p</i> = 0.028), though this association did not retain statistical significance after FDR correction.</p>\n <p><b>Conclusion:</b> These findings suggest that depression may causally influence the immune system by elevating overall WBC and basophil counts, with a marginally significant increase in lymphocyte levels. Conversely, higher monocyte count might confer some protection against depression, albeit with less statistial certainty. This study provides novel insights into the complex interplay between depression and immune function.</p>\n </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/3131579","citationCount":"0","resultStr":"{\"title\":\"Revealing the Causal Relationship Between Differential White Blood Cell Counts and Depression: A Bidirectional Two-Sample Mendelian Randomization Study\",\"authors\":\"Ying Cao, Xuguang Li, Jing Gao, Nan Zhang, Guoqian Zhang, Shen Li\",\"doi\":\"10.1155/da/3131579\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n <p><b>Background:</b> The link between white blood cells (WBC) and depression has been studied, but the causal relationship remains unclear. This study aimed to elucidate the potential bidirectional causal links between six specific WBC count features and depression using a two-sample Mendelian randomization (MR) analysis, leveraging summary statistics from genome-wide association studies (GWAS).</p>\\n <p><b>Method:</b> The dataset on depression (<i>N</i> = 406,986) was sourced from the FinnGen database, while the dataset on WBC (<i>N</i> = 563,085) was obtained from a combined dataset of Blood Cell Consortium (BCX) and UK Biobank. The MR analyses employed include inverse variance weighted (IVW), MR-Egger, weighted median, contamination mixture method (conmix), and constrained maximum likelihood-based Mendelian randomization (cML-MA). A threshold <i>p</i> < 0.05 after false discovery rate (FDR) correction was set as the criterion for causality based on IVW.</p>\\n <p><b>Results:</b> Reverse MR analysis indicated a causal relationship where depression leads to an increase in overall WBC count (IVW beta = 0.031, <i>p</i> = 0.015, <i>p</i><sub>FDR</sub> = 0.044) and specifically in basophil count (IVW beta = 0.038, <i>p</i> = 0.006, <i>p</i><sub>FDR</sub> = 0.038), with a marginally significant impact on lymphocyte count (beta = 0.029, <i>p</i> = 0.036, <i>p</i><sub>FDR</sub> = 0.071). Furthermore, forward MR analysis suggested a potential role of monocyte count in decreasing depression risk (<i>p</i> = 0.028), though this association did not retain statistical significance after FDR correction.</p>\\n <p><b>Conclusion:</b> These findings suggest that depression may causally influence the immune system by elevating overall WBC and basophil counts, with a marginally significant increase in lymphocyte levels. Conversely, higher monocyte count might confer some protection against depression, albeit with less statistial certainty. This study provides novel insights into the complex interplay between depression and immune function.</p>\\n </div>\",\"PeriodicalId\":55179,\"journal\":{\"name\":\"Depression and Anxiety\",\"volume\":\"2025 1\",\"pages\":\"\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-03-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/3131579\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Depression and Anxiety\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1155/da/3131579\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Depression and Anxiety","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/da/3131579","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Revealing the Causal Relationship Between Differential White Blood Cell Counts and Depression: A Bidirectional Two-Sample Mendelian Randomization Study
Background: The link between white blood cells (WBC) and depression has been studied, but the causal relationship remains unclear. This study aimed to elucidate the potential bidirectional causal links between six specific WBC count features and depression using a two-sample Mendelian randomization (MR) analysis, leveraging summary statistics from genome-wide association studies (GWAS).
Method: The dataset on depression (N = 406,986) was sourced from the FinnGen database, while the dataset on WBC (N = 563,085) was obtained from a combined dataset of Blood Cell Consortium (BCX) and UK Biobank. The MR analyses employed include inverse variance weighted (IVW), MR-Egger, weighted median, contamination mixture method (conmix), and constrained maximum likelihood-based Mendelian randomization (cML-MA). A threshold p < 0.05 after false discovery rate (FDR) correction was set as the criterion for causality based on IVW.
Results: Reverse MR analysis indicated a causal relationship where depression leads to an increase in overall WBC count (IVW beta = 0.031, p = 0.015, pFDR = 0.044) and specifically in basophil count (IVW beta = 0.038, p = 0.006, pFDR = 0.038), with a marginally significant impact on lymphocyte count (beta = 0.029, p = 0.036, pFDR = 0.071). Furthermore, forward MR analysis suggested a potential role of monocyte count in decreasing depression risk (p = 0.028), though this association did not retain statistical significance after FDR correction.
Conclusion: These findings suggest that depression may causally influence the immune system by elevating overall WBC and basophil counts, with a marginally significant increase in lymphocyte levels. Conversely, higher monocyte count might confer some protection against depression, albeit with less statistial certainty. This study provides novel insights into the complex interplay between depression and immune function.
期刊介绍：
Depression and Anxiety is a scientific journal that focuses on the study of mood and anxiety disorders, as well as related phenomena in humans. The journal is dedicated to publishing high-quality research and review articles that contribute to the understanding and treatment of these conditions. The journal places a particular emphasis on articles that contribute to the clinical evaluation and care of individuals affected by mood and anxiety disorders. It prioritizes the publication of treatment-related research and review papers, as well as those that present novel findings that can directly impact clinical practice. The journal's goal is to advance the field by disseminating knowledge that can lead to better diagnosis, treatment, and management of these disorders, ultimately improving the quality of life for those who suffer from them.
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