Dar Yoffe , Joseph GR. Paturzo , Alexandra Payne , Erin Hays , Michael Markel , Gaurav Bandi
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Paraneoplastic limbic encephalitis secondary to sertoli cell testicular tumor: A case report
Paraneoplastic Limbic Encephalitis (PLE) is a neurocognitive condition caused by an immune response to neuronal proteins linked to malignancy, such as testicular cancer. We report a 25-year-old male with cognitive and personality changes. His initial MRI showed vasogenic edema. A subsequent CT scan revealed bilateral hydroceles, and a follow-up scrotal US uncovered a right testicular mass, leading to a radical orchiectomy that confirmed a Sertoli cell tumor. Following orchiectomy and immunomodulating therapy, the patient's symptoms showed near-complete resolution within a year. This is the first documented case of PLE resulting from a non-germ cell testicular tumor.
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