3-氯胺酮与水杨醛一锅反应合成苯并呋喃[3,2-c]喹啉酮

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-02-27 DOI:10.1016/j.tet.2025.134568

Feng Wang , Sheng-Bin Wang , Jia-Qi Pan , Qiu-Yu Ma , Mingshu Wu , Rui Ning

引用次数: 0

摘要

以3-氯胺酮和水杨酸醛为原料，建立了一种温和高效的一锅合成苯并- [3,2-c]喹啉酮的反应。该方法涉及碱介导的二氢苯并呋喃螺恶哚中间体的形成，该中间体随后被TfOH催化转化为苯并呋喃[3,2-c]喹诺啉酮。该策略的特点是无过渡金属条件，易于获得的起始材料，和广泛的衬底范围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of benzofuro[3,2-c]quinolinones via one-pot reaction of 3-chlorooxindoles and salicylaldehydes

查看原文本刊更多论文

Synthesis of benzofuro[3,2-c]quinolinones via one-pot reaction of 3-chlorooxindoles and salicylaldehydes

A mild and efficient one-pot reaction for constructing benzofuro[3,2-c]quinolinones from 3-chlorooxindoles and salicylaldehydes is presented. The method involves the base-mediated formation of a dihydrobenzofuran spirooxindole intermediate, which is subsequently converted into benzofuro[3,2-c]quinolinones facilitated by TfOH. This strategy is characterized by transition metal-free conditions, easily accessible starting materials, and a broad substrate scope.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.