通过Cu(i)/ thbhp系统直接获得酰基化喹啉-2(1H)- 1 n-氧化物

IF 2.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

New Journal of Chemistry Pub Date : 2025-02-11 DOI:10.1039/D4NJ04823G

Jianxiong Xu, Xue Gong, Zhirui Wu, Weimin Huang and Jizhen Li

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引用次数: 0

摘要

对含氮杂环进行轻微修饰以获得结构新颖的化合物对于寻找有价值的生物分子具有重要意义。在本研究中，我们建立了一种简单实用的方法来合成c3酰化喹啉-2(1H)- 1的多种n-氧化物。首次公开了在Cu(I)/ thbhp条件下，通过C-H活化和自由基接力反应同时构建C-C和N-O键得到喹诺沙林-2(1H)- 1氧化物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Direct access to acylated quinoxalin-2(1H)-one N-oxides enabled by the Cu(i)/TBHP system†

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Direct access to acylated quinoxalin-2(1H)-one N-oxides enabled by the Cu(i)/TBHP system†

Slight modification of nitrogen-containing heterocycles to obtain structurally novel compounds is important in the search for valuable biological molecules. In this study, we established a simple and practical method for the synthesis of diverse N-oxides of C3-acylated quinoxalin-2(1H)-ones. Under Cu(I)/TBHP conditions, the simultaneous construction of C–C and N–O bonds to obtain quinoxalin-2(1H)-one oxides via C–H activation and radical relay reaction was disclosed for the first time.

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