高肌电刺激治疗截肢后疼痛的综述。

IF 1.4 Q4 CLINICAL NEUROLOGY
Syed I Khalid, Nikhil Veludandi, Chibueze Agwu, Konstantin V Slavin
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引用次数: 0

摘要

截肢后疼痛(PAP),包括残肢和幻肢疼痛,影响多达85%的截肢者,严重损害生活质量、活动能力和心理健康,同时产生大量医疗费用。传统的治疗方法——药物治疗和神经调节技术,如脊髓刺激和周围神经刺激——往往不能提供足够的缓解,并伴有阿片类药物依赖和全身毒性等不良反应。Altius高频神经阻滞系统是一种创新的治疗方法,它将高频交流电(HFAC)直接输送到周围神经,诱导可逆的传导阻滞,而不会产生感觉异常。通过关键的QUEST研究(一项多中心、双盲、随机、主动-虚假对照试验)的临床验证表明,慢性PAP患者疼痛强度显著降低,对止痛药的依赖减少。本文综述了HFAC神经阻滞的生理机制,概述了Altius系统的发展和临床应用,并评估了其安全性和对疼痛管理的广泛影响。研究结果表明,Altius系统解决了PAP治疗中的一个关键空白,提供持续的疼痛缓解,减少阿片类药物依赖,提高截肢者的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Altius electrical nerve stimulation for post-amputation pain treatment: a comprehensive review.

Post-amputation pain (PAP), which includes both residual limb and phantom limb pain, affects up to 85% of amputees and severely impairs quality of life, mobility, and psychological well-being while incurring substantial healthcare costs. Conventional treatments - pharmacotherapy and neuromodulation techniques such as spinal cord stimulation and peripheral nerve stimulation - often provide inadequate relief and are associated with adverse effects like opioid dependence and systemic toxicity. The Altius High-Frequency Nerve Block System is an innovative therapeutic approach that delivers high-frequency alternating current (HFAC) directly to peripheral nerves, inducing a reversible conduction block without paresthesia. Clinical validation through the pivotal QUEST study - a multicenter, double-blind, randomized, active-sham controlled trial - has shown significant reductions in pain intensity and decreased reliance on pain medications in patients with chronic PAP. This review examines the physiological mechanisms of HFAC nerve block, outlines the development and clinical application of the Altius system, and evaluates its safety profile and broader implications for pain management. The findings suggest that the Altius system addresses a critical gap in PAP treatment, offering sustained pain relief, reduced opioid dependency, and improved quality of life for amputees.

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来源期刊
Pain management
Pain management CLINICAL NEUROLOGY-
CiteScore
2.90
自引率
5.90%
发文量
62
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