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Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2025-02-01 DOI:10.31557/APJCP.2025.26.2.435

J Smith Torres-Roman, Gabriel De La Cruz-Ku, Christian S Alvarez, Jorge Ybaseta-Medina, Eloy F Ruiz, Jose Fabian Martinez-Herrera, Janina Bazalar-Palacios, Lita Del Rio-Muñiz, Julio A Poterico, Katherine A McGlynn

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引用次数: 0

摘要

背景：在秘鲁，肝癌是导致癌症相关死亡的主要原因之一，一些报告显示大城市的肝癌死亡率有所上升。据我们所知，近年来尚未开展过全国性或按地理区域划分的研究。因此，我们的目标是研究 2003-2017 年间秘鲁的总体、地区和性别肝癌死亡率：我们从秘鲁卫生部的死亡率数据库中检索了 2003 年至 2017 年期间的肝癌死亡数据。年龄标准化死亡率（ASMR）采用世界标准 SEGI 人口进行估算，以每 10 万人年为单位。我们使用 Joinpoint 回归程序 4.7.0 版分析了死亡率趋势。为了研究死亡率的空间分布，我们使用了 GeoDa 软件：2003年至2017年间，秘鲁共报告了31473例肝癌死亡病例。总体而言，自2005年以来，秘鲁妇女的肝癌死亡率显著下降（年均下降-3.1%），沿海和高原地区的降幅在2.8%至3.5%之间。在阿雷基帕、库斯科、拉利伯塔德、利马和莫克瓜，2003年至2017年期间的死亡率有所下降。在安卡什男性中，2003-2011年期间出现了显著增长（年均增长12.5），随后在2011-2017年期间出现了急剧下降（年均下降10.5）。相比之下，卡哈马卡、胡宁和乌卡亚利的死亡率在2003年至2017年间有所下降：虽然秘鲁一些地区的肝癌死亡率有所下降，但这些趋势在统计学上并不显著。此外，一些省份的肝癌死亡率有所上升。有效的干预措施，如扩大医疗保健的覆盖面和控制肝癌的各种风险因素，仍然是秘鲁面临的主要挑战。

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Liver Cancer Mortality Rates in Peru: Trend Analysis from 2003 to 2017.

Background: Liver cancer is one of the leading causes of cancer-related death in Peru, and some reports have indicated an increase in mortality rates among the largest cities. To our knowledge, no study has been carried out at a national level or by geographic area in recent years. Thus, our objective was to examine overall, regional and sex-specific liver cancer mortality rates in Peru between 2003-2017.

Methods: We retrieved data on liver cancer deaths between 2003 and 2017 from the mortality database of the Peruvian Ministry of Health. Age-standardized mortality rates (ASMR) were estimated per 100,000 person-years using the world standard SEGI population. We analyzed mortality trends using Joinpoint regression Program Version 4.7.0. To examine the spatial distribution of the mortality rates, we used GeoDa software.

Results: Between 2003 and 2017, 31,473 deaths from liver cancer were reported in Peru. Overall, liver cancer mortality rates have decreased significantly among Peruvian women since 2005 (-3.1% annually) with decreases in the coastal and highland regions ranging from 2.8% to 3.5%. In Arequipa, Cusco, La Libertad, Lima, and Moquegua, rates decreased bewteen 2003 and 2017. Among men in Ancash a significant increase (+12.5 annually) was observed from 2003-2011, followed by a sharpdecline (-10.5 annually) between 2011 and 2017. In contrast, rates in Cajamarca, Junin, and Ucayali decreased between 2003 and 2017.

Conclusions: Although decreases in liver cancer mortality rates were observed in some regions of Peru, these trends were not statistically significant. In addition, some provinces experienced increases in rates. Effective interventions, such as expanding access to healthcare and controlling the various risk factors for liver cancer, remains a key challenge for the country.

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.