经伽马射线照射的狗牙蔷薇对大鼠肺癌模型的抗肿瘤活性:一种拟议的机制。

IF 3.3 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
Omayma A R Abo-Zaid, Fatma S M Moawed, Eman S Eldin, Mostafa A Farrag, Esraa S A Ahmed
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引用次数: 0

摘要

背景:肺癌是全球最常见的恶性肿瘤之一,也是癌症相关死亡的主要原因。顺铂是一种应用广泛的化疗药物,但其毒副作用大,影响临床疗效。摘要犬玫瑰是一种药用植物,具有抗炎、抗癌、免疫调节、抗氧化和基因保护等一系列有益的生物活性。方法:在雌性大鼠二甲苯并(a)蒽致肺癌模型中,研究犬月牙对顺铂抗癌作用的增强作用。这些动物被给予玫瑰,顺铂,或两种治疗的组合。评估关键信号分子的表达水平,包括磷酸肌苷-3激酶(PI3K)、Akt、哺乳动物雷帕霉素靶点(mTOR)、裂解聚(adp核糖)聚合酶(PARP-1)、髓样分化因子88 (MyD88)、肿瘤坏死因子受体相关因子(TRAF)以及各种自噬标志物。此外,我们评估了肺组织中toll样受体2 (TLR2)、核因子κB (NF-κB)和凋亡标志物的水平,并辅以组织病理学检查。结果:犬月果提取物联合顺铂通过下调PARP-1、TLR2/MyD88/TRAF6/NF-κB信号通路以及PI3K/Akt/mTOR信号通路,显著抑制肺癌细胞增殖。此外,这种联合治疗促进自噬和凋亡,自噬和凋亡标志物水平升高证明。结论:综上所述,本研究结果提示,犬月牙通过抑制癌细胞增殖,同时诱导自噬和凋亡,从而增强顺铂的抗癌作用。因此,Rosa可作为顺铂化疗的辅助药物,克服其局限性,不失为肺癌治疗策略中的一种新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antitumor activity of gamma-irradiated Rosa canina L. against lung carcinoma in rat model: a proposed mechanism.

Background: Lung cancer is one of the most prevalent malignancies globally and is the leading cause of cancer-related mortality. Although cisplatin is a widely utilized chemotherapeutic agent, its clinical efficacy is often hampered by significant toxicity and undesirable side effects. Rosa canina, a medicinal plant, has demonstrated a range of beneficial biological activities, including anti-inflammatory, anticancer, immunomodulatory, antioxidant, and genoprotective effects.

Methods: This study aimed to investigate the potential of Rosa canina to enhance the anticancer efficacy of cisplatin in a dimethyl benz(a)anthracene-induced lung cancer model using female rats. The animals were administered Rosa canina, cisplatin, or a combination of both treatments. The expression levels of critical signaling molecules were evaluated, including phosphoinositide-3-kinase (PI3K), Akt, mammalian target of rapamycin (mTOR), cleaved poly (ADP-ribose) polymerase (PARP-1), myeloid differentiation factor 88 (MyD88), and tumor necrosis factor receptor-associated factor (TRAF), in addition to various autophagic markers. Furthermore, we assessed the levels of toll-like receptor 2 (TLR2), nuclear factor kappa B (NF-κB), and apoptotic markers in lung tissue, complemented by histopathological examinations.

Results: The combined treatment of Rosa canina extract and cisplatin significantly inhibited lung cancer cell proliferation by downregulating PARP-1 and the TLR2/MyD88/TRAF6/NF-κB signaling pathway, as well as the PI3K/Akt/mTOR pathway. Moreover, this combination therapy promoted autophagy and apoptosis, evidenced by elevated levels of autophagic and apoptotic markers.

Conclusion: Overall, the findings of this study suggest that Rosa canina enhances the anticancer effects of cisplatin by inhibiting cancer cell proliferation while simultaneously inducing autophagy and apoptosis. Thus, Rosa can be used as adjuvant to cisplatin chemotherapy to overcome its limitations which may be considered a new approach during lung cancer treatment strategy.

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来源期刊
BMC Complementary Medicine and Therapies
BMC Complementary Medicine and Therapies INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
6.10
自引率
2.60%
发文量
300
审稿时长
19 weeks
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