含三萜、环蒿烯酮和环蒿烯醇的环丙烷：分离、化学转化和抗癌研究

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

ChemistrySelect Pub Date : 2025-03-03 DOI:10.1002/slct.202403698

Sayantan Paul, Kartik Mandal, Manas K. Santra, Asish K. Bhattacharya

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引用次数: 0

摘要

环木菠萝烯酮和环木菠萝烯醇这两种植物源三萜类化合物具有环丙烷环，它们是从异叶菠萝蒿（千层塔）的乳汁中分离出来的。环木菠萝烯醇通过乙酰化和脱乙酰化方法进行化学修饰，然后加氢合成二氢环木菠萝烯醇。环木菠萝烯醇中的羟基也被用于形成硝基苯甲酸酯。所有分离和合成的化合物都针对 MCF7 乳腺癌细胞系进行了抗癌特性检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cyclopropane Containing Triterpenoids, Cycloartenone, and Cycloartenol: Isolation, Chemical Transformations, and Anticancer Studies

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Cyclopropane Containing Triterpenoids, Cycloartenone, and Cycloartenol: Isolation, Chemical Transformations, and Anticancer Studies

Cycloartenone and cycloartenol, two plant-derived triterpenoids possessing cyclopropane ring were isolated from the latex of Artocarpus heterophyllus (jackfruit). Cycloartenol was chemically modified to synthesize dihydrocycloartenol via acetylation and deacetylation methodology followed by hydrogenation. Hydroxyl group present in the cycloartenol was also employed for the nitro benzoate formation. All the isolated and synthesized compounds were assayed against MCF7 breast cancer cell line for their anticancer properties.

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来源期刊

ChemistrySelect Chemistry-General Chemistry

CiteScore

3.30

自引率

4.80%

发文量

1809

审稿时长

1.6 months

期刊介绍： ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.