m痘患者的信号换能器和转录激活子1功能获得突变

IF 6.9 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings Pub Date : 2025-03-01 DOI:10.1016/j.mayocp.2024.11.022

Jack W. McHugh MB BCh BAO , Eric O. Gomez MD , Omar M. Abu-Saleh MB BS , Cristina G. Corsini Campioli MD , Supavit Chesdachai MD , Saadiya Nazli MB BS , Nicholas T. Streck PhD , Shama Cash-Goldwasser MD , Agam K. Rao MD , Michelle L. Meyer PhD , Avni Y. Joshi MD , Kevin P. Boyd MD , Julian A. Villalba MD , Reade A. Quinton MD , Pritish K. Tosh MD , Aditya S. Shah MB BS

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引用次数: 0

摘要

我们报告一例m痘患者的信号换能器和转录激活子1功能获得突变。尽管最初通过静脉注射免疫球蛋白和替可韦莫得到改善，但出现了严重症状，患者死亡。这强调需要免疫系统优化和有效的病毒治疗m痘。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Mpox in a Patient With a Signal Transducer and Activator of Transcription 1 Gain-of-Function Mutation

We report a case of mpox in a patient with a signal transducer and activator of transcription 1 gain-of-function mutation. Despite initial improvement with intravenous immune globulin and tecovirimat, severe symptoms developed and the patient died. This underscores the need for immune system optimization and effective virucidal treatments for mpox.

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来源期刊

Mayo Clinic proceedings 医学-医学：内科

CiteScore

16.80

自引率

1.10%

发文量

383

审稿时长

37 days

期刊介绍： Mayo Clinic Proceedings is a premier peer-reviewed clinical journal in general medicine. Sponsored by Mayo Clinic, it is one of the most widely read and highly cited scientific publications for physicians. Since 1926, Mayo Clinic Proceedings has continuously published articles that focus on clinical medicine and support the professional and educational needs of its readers. The journal welcomes submissions from authors worldwide and includes Nobel-prize-winning research in its content. With an Impact Factor of 8.9, Mayo Clinic Proceedings is ranked #20 out of 167 journals in the Medicine, General and Internal category, placing it in the top 12% of these journals. It invites manuscripts on clinical and laboratory medicine, health care policy and economics, medical education and ethics, and related topics.